Integrating clinical, gene expression, protein expression and preanalytical data for in silico cancer research

被引：0
作者：
Rossille, Delphine [1 ]
Burgun, Anita [1 ]
Pangault-Lorho, Celine [1 ]
Fest, Thierry [1 ]
机构：
[1] CHU Rennes, Dept Med Informat, 2 Rue Henri Le Guilloux, F-35033 Rennes, France
来源：
EHEALTH BEYOND THE HORIZON - GET IT THERE | 2008年 / 136卷
关键词：
Systems integration; Information storage and retrieval; Databases; Genetic; Cancer;
D O I：
暂无
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
We present the phase I development of an integrative platform for the analysis of clinical, gene expression, protein expression and pre-analytical data. The platform is aimed at providing transparent access and analysis tools to researchers investigating new biomarkers and prognosis factors in the particular field of lymphoma diseases. In this article, we report on the data integration phase. The platform's principal advantage is its completeness as it integrates in a single environment clinical, genomic and proteomic data, allowing for their combined analysis. The architecture consists in a data warehouse including data on patients, clinical trials and array platforms and a DeMilitarized Zone for data exchange. A secure web-based platform allows any collaborative team to request the data warehouse and access basic statistics on integrated data. The presented system is currently in use.
引用
收藏
页码：455 / +
页数：2
相关论文
共 12 条
[1]   Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets [J].
Chelala, Claude ;
Hahn, Stephan A. ;
Whiteman, Hannah J. ;
Barry, Sayka ;
Hariharan, Deepak ;
Radon, Tomasz P. ;
Lemoine, Nicholas R. ;
Crnogorac-Jurcevic, Tatjana .
BMC GENOMICS, 2007, 8 (1)
[2]   caCORE: A common infrastructure for cancer informatics [J].
Covitz, PA ;
Hartel, F ;
Schaefer, C ;
De Coronado, S ;
Fragoso, G ;
Sahni, H ;
Gustafson, S ;
Buetow, KH .
BIOINFORMATICS, 2003, 19 (18) :2404-2412
[3]   ITTACA: a new database for integrated tumor transcriptome array and clinical data analysis [J].
Elfilali, Adil ;
Lair, Severine ;
Verbeke, Catia ;
La Rosa, Philippe ;
Radvanyi, Francois ;
Barillot, Emmanuel .
NUCLEIC ACIDS RESEARCH, 2006, 34 :D613-D616
[4]  
HIJIKATA A, 2007, BIOINFORMATICS 0925
[5]   Biomedical informatics: development of a comprehensive data warehouse for clinical and genomic breast cancer research [J].
Hu, H ;
Brzeski, H ;
Hutchins, J ;
Ramaraj, M ;
Qu, L ;
Xiong, R ;
Kalathil, S ;
Kato, R ;
Tenkillaya, S ;
Carney, J ;
Redd, R ;
Arkalgudvenkata, S ;
Shahzad, K ;
Scott, R ;
Cheng, H ;
Meadow, S ;
McMichael, J ;
Sheu, SL ;
Rosendale, D ;
Kvecher, L ;
Ahern, S ;
Yang, S ;
Zhang, YH ;
Jordan, R ;
Somiari, S ;
Hooke, J ;
Shriver, CD ;
Somiari, RI ;
Liebman, MN .
PHARMACOGENOMICS, 2004, 5 (07) :933-941
[6]   CIBEX: Center for information biology gene EXpression database [J].
Ikeo, K ;
Ishi-i, J ;
Tamura, T ;
Gojobori, T ;
Tateno, Y .
COMPTES RENDUS BIOLOGIES, 2003, 326 (10-11) :1079-1082
[7]   Expression Profiler:: next generation-an online platform for analysis of microarray data [J].
Kapushesky, M ;
Kemmeren, P ;
Culhane, AC ;
Durinck, S ;
Ihmels, J ;
Körner, C ;
Kull, M ;
Torrente, A ;
Sarkans, U ;
Vilo, J ;
Brazma, A .
NUCLEIC ACIDS RESEARCH, 2004, 32 :W465-W470
[8]  
Kato K, 2005, NUCLEIC ACIDS RES, V33, pD533
[9]  
NAGARAJAN A, 2004, P 30 VLDB C TOR CAN, P1202
[10]   Stakes of pre-analytical parameters in blood transcriptomic and proteomic analysis.: Application to clinical research:: the GOELAMS trial [J].
Pangoult, C. ;
Arlotto, Marie ;
Berger, Francois ;
De Vos, John ;
Bene, Marie-Christine ;
Fest, Thierry .
M S-MEDECINE SCIENCES, 2007, 23 :13-17
12