Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma

被引:7
作者
Jeon, Soo Ji [1 ]
Jung, Kyoung In [2 ]
Park, Chan Kee [2 ]
Park, Hae-Young Lopilly [2 ]
机构
[1] Catholic Univ Korea, Coll Med, Dept Ophthalmol, Bucheon St Marys Hosp, Bucheon 14647, South Korea
[2] Catholic Univ Korea, Coll Med, Dept Ophthalmol, Seoul St Marys Hosp, Seoul 06591, South Korea
关键词
normal tension glaucoma; pattern electroretinogram; optical coherence tomography angiography; macular vessel density; COHERENCE TOMOGRAPHY ANGIOGRAPHY; GANGLION-CELL FUNCTION; OPEN-ANGLE GLAUCOMA; VESSEL DENSITY LOSS; PROGRESSION; THICKNESS; DIAGNOSIS; SEVERITY;
D O I
10.3390/jcm11071790
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: To investigate whether macular vessel density (VD) was associated with the pattern electroretinogram (PERG) in normal tension glaucoma (NTG). Design: Cross-sectional study. Methods: Seventy-six eyes from patients with NTG were included in this study. Macular VD was calculated from the superficial retinal layer, including the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), using the built-in software provided with the optical coherence tomography angiography (OCTA) device. Functional parameters were obtained from standard automated perimetry (SAP) and PERG, using a commercial ERG stimulator. Moreover, structural parameters, such as peripapillary RNFL and macular ganglion cell/inner plexiform layer (GCIPL) thickness, were measured using OCT. Results: Patients with higher VD had higher N95 amplitude (p = 0.048). Macular VD was significantly correlated with N95 amplitude, irrespective of disease severity (r = 0.352, p = 0.002 for the total subjects and r = 0.276, p = 0.043 for mild glaucoma). According to regression analyses, N95 amplitude and macular VD were bidirectional significant factors (p = 0.035 and 0.019, respectively). For patients with mild to moderate glaucoma, N95 amplitude and macular VD were also significantly associated bidirectionally, according to regression analyses (p = 0.032 and 0.040, respectively). Conclusions: Macular VD was significantly associated with N95 amplitude from PERG. The correlation was prominent in early glaucoma, in contrast to the other structural or functional parameters. When considering that PERG represents the objective function of the retinal ganglion cell (RGC), macular VD was associated with RGC dysfunction before the functional change became apparent on SAP.
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页数:12
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