The metabolism-modulating activity of IL-17 signaling in health and disease

被引：67

作者：

Bechara, Rami ^{[1
]}

McGeachy, Mandy J. ^{[1
]}

Gaffen, Sarah L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15260 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2021年 / 218卷 / 05期

基金：

美国国家卫生研究院;

关键词：

NECROSIS-FACTOR-ALPHA; KAPPA-B-ZETA; REGULATORY T-CELLS; RHEUMATOID-ARTHRITIS; INADEQUATE RESPONSE; GLUCOSE-HOMEOSTASIS; MONOCLONAL-ANTIBODY; ADIPOSE-TISSUE; INTERLEUKIN; 17; HOST-DEFENSE;

D O I：

10.1084/jem.20202191

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-17 was discovered nearly 30 yr ago, but it has only been recently appreciated that a key function of this cytokine is to orchestrate cellular and organismal metabolism. Indeed, metabolic regulation is integrated into both the physiological and the pathogenic aspects of IL-17 responses. Thus, understanding the interplay between IL-17 and downstream metabolic processes could ultimately inform therapeutic opportunities for diseases involving IL-17, including some not traditionally linked to this cytokine pathway. Here, we discuss the emerging pathophysiological roles of IL-17 related to cellular and organismal metabolism, including metabolic regulation of IL-17 signal transduction.

引用

页数：13

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