Cocaine downregulates the expression of the mitochondrial genome in rat brain

被引：27

作者：

Dietrich, JB ^{[1
]}

Poirier, R ^{[1
]}

Aunis, D ^{[1
]}

Zwiller, J ^{[1
]}

机构：

[1] INSERM, U 575, Ctr Neurochem, F-67084 Strasbourg, France

来源：

CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY | 2004年 / 1025卷

关键词：

cocaine; mitochondrial genes; rat brain;

D O I：

10.1196/annals.1316.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis by differential display of genes induced in response to acute cocaine administration to rats revealed the significant downregulation of several mitochondrial genes in the cingulate cortex, including the subunits 1, 2, 4, 5, and 6 of NADH dehydrogenase and the subunit 2 of cytochrome c oxidase. Although the mechanism of the downregulation of expression of these mitochondrial genes by cocaine is presently not well understood, one can envisage that it involves an increased production of reactive oxygen species in cells of the cerebral cortex.

引用

页码：345 / 350

页数：6

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