Development of functionalized polyetherimide/polyvinylpyrrolidone membranes for application in hemodialysis

被引：13

作者：

dos Santos, Alana Melo ^{[1
]}

Habert, Alberto Claudio ^{[1
]}

Ferraz, Helen Conceicao ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, COPPE UFRJ, Chem Engn Program, POB 68502, BR-21941972 Rio De Janeiro, RJ, Brazil

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2017年 / 28卷 / 09期

关键词：

HEPARIN CONJUGATE; POLYSULFONE; HEMOCOMPATIBILITY; IMMOBILIZATION; PERMEABILITY; REMOVAL; BIOCOMPATIBILITY; PERFORMANCE; ADSORPTION; CHITOSAN;

D O I：

10.1007/s10856-017-5946-z

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The present study aimed to synthesize membranes for hemodialysis based on polyetherimide (PEI) and polyvinylpyrrolidone (PVP), with chemical immobilization of heparin on its surface to increase blood compatibility. The synthesized PEI/PVP membranes were characterized by morphological analysis and transport properties, as well by infrared spectroscopy (FT-IR), protein adsorption, contact angle, activated partial thromboplastin time (aPTT), and platelet adhesion. Hydraulic permeability of the synthesized PEI membranes were comparable to those of current high flux clinical membranes; values of diffusive permeability and rejection for typical solutes were similar to those reported in literature. The immobilization of heparin, in turn, resulted in more hydrophilic membranes, with insignificant protein adsorption and platelet adhesion (as opposed to actual clinical membranes), indicating antithrombogenic characteristics as confirmed by increased aPTT.

引用

页数：9

共 35 条

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