Melatonin: does it have utility in the treatment of haematological neoplasms?

被引：47

作者：

Li, Tian ^{[1
,2
]}

Yang, Zhi ^{[2
]}

Jiang, Shuai ^{[3
]}

Di, Wencheng ^{[4
]}

Ma, Zhiqiang ^{[5
]}

Hu, Wei ^{[2
]}

Chen, Fulin ^{[1
]}

Reiter, Russel J. ^{[6
]}

Yang, Yang ^{[1
,2
]}

机构：

[1] Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Fac Life Sci, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Dept Biomed Engn, Xian, Shaanxi, Peoples R China

[3] Fourth Mil Med Univ, Dept Aerosp Med, Xian, Shaanxi, Peoples R China

[4] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Cardiol, Med Sch, Nanjing, Jiangsu, Peoples R China

[5] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, Xian, Shaanxi, Peoples R China

[6] UT Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2018年 / 175卷 / 16期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

CYCLOPHOSPHAMIDE PLUS SOMATOSTATIN; ISCHEMIA-REPERFUSION INJURY; CHRONIC LYMPHOCYTIC-LEUKEMIA; CONCISE GUIDE; OXIDATIVE STRESS; CANCER CELLS; PROMYELOCYTIC LEUKEMIA; INDUCED APOPTOSIS; FIELD EXPOSURE; ADVANCED-STAGE;

D O I：

10.1111/bph.13966

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Melatonin, discovered in 1958 in the bovine pineal tissue, is an indoleamine that modulates circadian rhythms and has a wide variety of other functions. Haematological neoplasms are the leading cause of death in children and adolescents throughout the world. Research has demonstrated that melatonin is a low-toxicity protective molecule against experimental haematological neoplasms, but the mechanisms remain poorly defined. Here, we provide an introduction to haematological neoplasms and melatonin, especially as they relate to the actions of melatonin on haematological carcinogenesis. Secondly, we summarize what is known about the mechanisms of action of melatonin in the haematological system, including its pro-apoptotic, pro-oxidative, anti-proliferative and immunomodulatory actions. Thirdly, we discuss the advantages of melatonin in combination with other drugs against haematological malignancy, as well as its other benefits on the haematological system. Finally, we summarize the findings that are contrary to the suppressive effects of melatonin on cancers of haematological origin. We hope that this information will be helpful in the design of studies related to the therapeutic efficacy of melatonin in haematological neoplasms.

引用

页码：3251 / 3262

页数：12

共 128 条

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