Abnormal Activation of the Social Brain Network in Children with Autism Spectrum Disorder: An fMRI Study

被引:43
作者
Kim, Sun-Young [1 ]
Choi, Uk-Su [2 ]
Park, Sung-Yeon [2 ]
Oh, Se-Hong [2 ]
Yoon, Hyo-Woon [3 ]
Koh, Yun-Joo [4 ,5 ]
Im, Woo-Young [6 ]
Park, Jee-In [7 ,8 ]
Song, Dong-Ho [7 ,8 ]
Cheon, Keun-Ah [7 ,8 ]
Lee, Chang-Uk [9 ]
机构
[1] Sungmo Maum Psychiat Clin, Seoul, South Korea
[2] Gachon Univ Med & Sci, Neurosci Res Inst, Inchon, South Korea
[3] Daegu Cyber Univ, Dept Art Therapy, Taegu, South Korea
[4] Korea Inst Childrens Social Dev, Seoul, South Korea
[5] Rudolph Child Res Ctr, Seoul, South Korea
[6] Konyang Univ, Coll Med, Dept Psychiat, Taejon, South Korea
[7] Yonsei Univ, Coll Med, Div Child & Adolescent Psychiat, Dept Psychiat, Seoul 120752, South Korea
[8] Yonsei Univ, Coll Med, Inst Behav Sci Med, Seoul 120752, South Korea
[9] Catholic Univ Korea, Seoul St Marys Hosp, Dept Psychiat, Seoul, South Korea
关键词
Autism spectrum disorder; Social brain network; Social cognition; fMRI; NEURAL SYSTEMS; DIAGNOSTIC INTERVIEW; MECHANISMS; IMITATION; DEFICITS; FACE; METAANALYSIS; ADOLESCENTS; PERCEPTION; AWARENESS;
D O I
10.4306/pi.2015.12.1.37
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective The aim of this study is to investigate abnormal findings of social brain network in Korean children with autism spectrum disorder (ASD) compared with typically developing children (TDC). Methods Functional magnetic resonance imaging (fiVIRI) was performed to examine brain activations during the processing of emotional faces (happy, fearful, and neutral) in 17 children with ASD, 24 TDC. Results When emotional face stimuli were given to children with ASD, various areas of the social brain relevant to social cognition showed reduced activation. Specifically, ASD children exhibited less activation in the right amygdala (AMY), right superior temporal sulcus (STS) and right inferior frontal gyrus (IFG) than TDC group when fearful faces were shown. Activation of left insular cortex and right IFG in response to happy faces was less in the ASD group. Similar findings were also found in left superior insular gyrus and right insula in case of neutral stimulation. Conclusion These findings suggest that children with ASD have different processing of social and emotional experience at the neural level. In other words, the deficit of social cognition in ASD could be explained by the deterioration of the capacity for visual analysis of emotional faces, the subsequent inner imitation through mirror neuron system (MNS), and the ability to transmit it to the limbic system and to process the transmitted emotion.
引用
收藏
页码:37 / 45
页数:9
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