Synthesis of chiral quaternary fluorinated cyclic sulfamidates via palladium-catalyzed arylation with arylboronic acids

被引：8
作者：
Chen, Mu-Wang [1 ,2 ]
Mao, Xuechun [1 ,2 ]
Ji, Yue [3 ]
Yuan, Jianjun [1 ,2 ]
Deng, Zhihong [1 ,2 ]
Peng, Yiyuan [1 ,2 ]
机构：
[1] Minist Educ, Jiangxi Prov Key Lab Green Chem, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
[2] Jiangxi Normal Univ, Nanchang 330022, Jiangxi, Peoples R China
[3] Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Shaanxi, Peoples R China
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 48期
基金：
中国国家自然科学基金;
关键词：
Asymmetric-addition; Quaternary fluorinated cyclic sulfamidate; Palladium catalyst; Arylboronic acid; PD(II)-CATALYZED ASYMMETRIC ADDITION; C-H AMINATION; ENANTIOSELECTIVE SYNTHESIS; NUCLEOPHILIC ALLYLATION; IMINES; LIGANDS; ACCESS; TRIFLUOROMETHYLATION; CYTOCHROME-P450; HYDRAZONES;
D O I：
10.1016/j.tetlet.2019.151280
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantioselective palladium-catalyzed arylation of fluorinated cyclic N-sulfonyl ketimines with arylboronic acids is described. This methodology provides an efficient and convenient route to chiral quaternary fluorinated cyclic sulfamidates in high yields with up to 99% ee. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：4
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