Thiol-reactive (co)polymer scaffolds comprising organic arsenical acrylamides

被引：9

作者：

Footman, Charlotte ^{[1
]}

de Jongh, Patrick A. J. M. ^{[1
]}

Tanaka, Joji ^{[1
]}

Peltier, Raoul ^{[1
]}

Kempe, Kristian ^{[1
,2
]}

Davis, Thomas P. ^{[1
,2
]}

Wilson, Paul ^{[1
,2
]}

机构：

[1] Univ Warwick, Chem Dept, Lib Rd, Coventry CV4 7AL, W Midlands, England

[2] Monash Univ, ARC Ctr Excellence Convergent Bionano Sci & Techn, Monash Inst Pharmaceut Sci, Parkville Campus,399 Royal Parade, Parkville, Vic 3152, Australia

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 60期

基金：

澳大利亚国家健康与医学研究理事会; 英国工程与自然科学研究理事会;

关键词：

LIVING RADICAL POLYMERIZATION; RAFT POLYMERIZATION; POLYMERS; COPOLYMERS; MONOMERS; NANOPARTICLES; CONJUGATION; EFFICIENT; BRUSHES;

D O I：

10.1039/c7cc03880a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel, well-defined organic arsenical homopolymers (D = 1.10-1.40) have been synthesised via RAFT polymerisation. Copolymerisation of the As-functional monomer with dimethylacrylamide yielded nontoxic polymer scaffolds (D approximate to 1.10) that could be manipulated in response to pH and undergo sequential reduction and substitution in the presence of thiols including cysteine and glutathione.

引用

页码：8447 / 8450

页数：4

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