Thiol-reactive (co)polymer scaffolds comprising organic arsenical acrylamides

被引：11

作者：

Footman, Charlotte ^{[1
]}

de Jongh, Patrick A. J. M. ^{[1
]}

Tanaka, Joji ^{[1
]}

Peltier, Raoul ^{[1
]}

Kempe, Kristian ^{[1
,2
]}

Davis, Thomas P. ^{[1
,2
]}

Wilson, Paul ^{[1
,2
]}

机构：

[1] Univ Warwick, Chem Dept, Lib Rd, Coventry CV4 7AL, W Midlands, England

[2] Monash Univ, ARC Ctr Excellence Convergent Bionano Sci & Techn, Monash Inst Pharmaceut Sci, Parkville Campus,399 Royal Parade, Parkville, Vic 3152, Australia

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 60期

基金：

英国工程与自然科学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

LIVING RADICAL POLYMERIZATION; RAFT POLYMERIZATION; POLYMERS; COPOLYMERS; MONOMERS; NANOPARTICLES; CONJUGATION; EFFICIENT; BRUSHES;

D O I：

10.1039/c7cc03880a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel, well-defined organic arsenical homopolymers (D = 1.10-1.40) have been synthesised via RAFT polymerisation. Copolymerisation of the As-functional monomer with dimethylacrylamide yielded nontoxic polymer scaffolds (D approximate to 1.10) that could be manipulated in response to pH and undergo sequential reduction and substitution in the presence of thiols including cysteine and glutathione.

引用

页码：8447 / 8450

页数：4

共 29 条

[1] MODEL REACTIONS FOR SYNTHESIS OF PHARMACOLOGICALLY ACTIVE POLYMERS BY WAY OF MONOMERIC AND POLYMERIC REACTIVE ESTERS [J].

BATZ, HG ;

FRANZMANN, G ;

RINGSDORF, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1972, 11 (12) :1103-1104

[2] Controlled/living radical polymerization: Features, developments, and perspectives [J].

Braunecker, Wade A. ;

Matyjaszewski, Krzysztof .

PROGRESS IN POLYMER SCIENCE, 2007, 32 (01) :93-146

[3] The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension [J].

Duong, Hien T. T. ;

Dong, Zhixia ;

Su, Lin ;

Boyer, Cyrille ;

George, Jacob ;

Davis, Thomas P. ;

Wang, Jianhua .

SMALL, 2015, 11 (19) :2291-2304

[4] Controlled growth and subsequent chemical modification of poly(glycidyl methacrylate) brushes on silicon wafers [J].

Edmondson, S ;

Huck, WTS .

JOURNAL OF MATERIALS CHEMISTRY, 2004, 14 (04) :730-734

[5]

Friedheim E, 1947, United States Patent, Patent No. [US2422724 A, 2422724]

[6] Rapid and quantitative one-pot synthesis of sequence-controlled polymers by radical polymerization [J].

Gody, Guillaume ;

Maschmeyer, Thomas ;

Zetterlund, Per B. ;

Perrier, Sebastien .

NATURE COMMUNICATIONS, 2013, 4

[7] Combination therapy: Opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines [J].

Greco, Francesca ;

Vicent, Maria J. .

ADVANCED DRUG DELIVERY REVIEWS, 2009, 61 (13) :1203-1213

[8] Standing on the shoulders of hermann staudinger: Post-polymerization modification from past to present [J].

Guenay, Kemal Arda ;

Theato, Patrick ;

Klok, Harm-Anton .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2013, 51 (01) :1-28

[9] A guide to the synthesis of block copolymers using reversible-addition fragmentation chain transfer (RAFT) polymerization [J].

Keddie, Daniel J. .

CHEMICAL SOCIETY REVIEWS, 2014, 43 (02) :496-505

[10] Synthesis of neoglycopolymers by a combination of "click chemistry" and living radical polymerization [J].

Ladmiral, V ;

Mantovani, G ;

Clarkson, GJ ;

Cauet, S ;

Irwin, JL ;

Haddleton, DM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (14) :4823-4830

← 1 2 3 →