Crystal structure of 3-(2-chloro-benzyl)-7-[4-(2-chloro-benzyl)-piperazin-1-yl]-5,6,8-trifluoro-3H-quinazolin-4-one, C26H21Cl2F3N4O

被引:1
作者
Fang, Shu-Fen [3 ]
Peng, Wen-Wen [4 ]
Xiong, Yuan-Zhen [5 ]
Nie, Xu-Liang [1 ]
Huang, Jian-Ping [2 ]
机构
[1] Jiangxi Agr Univ, Key Lab Chem Utilizat Plant Resources Nanchang, Dept Chem, Nanchang 330045, Jiangxi, Peoples R China
[2] Jiangxi Agr Univ, Key Lab Chem Utilizat Plant Resources Nanchang, Jiangxi Key Lab Conservat & Utilizat Fungal Resou, Dept Chem, Nanchang 330031, Jiangxi, Peoples R China
[3] Jiangxi Prov Maternal & Child Hlth Hosp, Dept Gynaecol, Nanchang 330006, Jiangxi, Peoples R China
[4] Jiangxi Agr Univ, Lab Phytochem & Bot Pesticides, Coll Agr, Nanchang 330045, Jiangxi, Peoples R China
[5] Nanchang Univ, Coll Pharm, Nanchang 330031, Jiangxi, Peoples R China
来源
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES | 2021年 / 236卷 / 04期
关键词
RAS ONCOGENES; CANCER;
D O I
10.1515/ncrs-2021-0085
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
C26H21Cl2F3N4O, monoclinic, Pc (no. 7), a = 21.218(6) angstrom, b = 5.9599(16) angstrom, c = 9.439(3) angstrom, beta = 99.295(3)degrees, V = 1177.9(5) angstrom(3), Z = 2, R-gt(F) = 0.0471, w(Rre)f(F-2) = 0.1282, T = 296(2) K.
引用
收藏
页码:815 / 817
页数:3
相关论文
共 16 条
  • [1] [Anonymous], 2009, APEX2 SAINT SADABS
  • [2] Genomic analyses identify molecular subtypes of pancreatic cancer
    Bailey, Peter
    Chang, David K.
    Nones, Katia
    Johns, Amber L.
    Patch, Ann-Marie
    Gingras, Marie-Claude
    Miller, David K.
    Christ, Angelika N.
    Bruxner, Tim J. C.
    Quinn, Michael C.
    Nourse, Craig
    Murtaugh, L. Charles
    Harliwong, Ivon
    Idrisoglu, Senel
    Manning, Suzanne
    Nourbakhsh, Ehsan
    Wani, Shivangi
    Fink, Lynn
    Holmes, Oliver
    Chin, Vencssa
    Anderson, Matthew J.
    Kazakoff, Stephen
    Leonard, Conrad
    Newell, Felicity
    Waddell, Nick
    Wood, Scott
    Xu, Qinying
    Wilson, Peter J.
    Cloonan, Nicole
    Kassahn, Karin S.
    Taylor, Darrin
    Quek, Kelly
    Robertson, Alan
    Pantano, Lorena
    Mincarelli, Laura
    Sanchez, Luis N.
    Evers, Lisa
    Wu, Jianmin
    Pinese, Mark
    Cowley, Mark J.
    Jones, Marc D.
    Colvin, Emily K.
    Nagrial, Adnan M.
    Humphrey, Emily S.
    Chantrill, Lorraine A.
    Mawson, Amanda
    Humphris, Jeremy
    Chou, Angela
    Pajic, Marina
    Scarlett, Christopher J.
    [J]. NATURE, 2016, 531 (7592) : 47 - +
  • [3] BOS JL, 1989, CANCER RES, V49, P4682
  • [4] Brandenburg K., 2015, VISUAL CRYSTAL STRUC
  • [5] Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
    Campbell, Joshua D.
    Alexandrov, Anton
    Kim, Jaegil
    Wala, Jeremiah
    Berger, Alice H.
    Pedamallu, Chandra Sekhar
    Shukla, Sachet A.
    Guo, Guangwu
    Brooks, Angela N.
    Murray, Bradley A.
    Imielinski, Marcin
    Hu, Xin
    Ling, Shiyun
    Akbani, Rehan
    Rosenberg, Mara
    Cibulskis, Carrie
    Ramachandran, Aruna
    Collisson, Eric A.
    Kwiatkowski, David J.
    Lawrence, Michael S.
    Weinstein, John N.
    Verhaak, Roel G. W.
    Wu, Catherine J.
    Hammerman, Peter S.
    Cherniack, Andrew D.
    Getz, Gad
    Artyomov, Maxim N.
    Schreiber, Robert
    Govindan, Ramaswamy
    Meyerson, Matthew
    [J]. NATURE GENETICS, 2016, 48 (06) : 607 - +
  • [6] Targeting ras signalling pathways in cancer therapy
    Downward, J
    [J]. NATURE REVIEWS CANCER, 2003, 3 (01) : 11 - 22
  • [7] Giannakis M, 2016, CELL REP, V15, P857, DOI 10.1016/j.celrep.2016.03.075
  • [8] Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression
    Holland, Jason P.
    Jones, Michael W.
    Cohrs, Susan
    Schibli, Roger
    Fischer, Eliane
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (02) : 496 - 507
  • [9] Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
    Janes, Matthew R.
    Zhang, Jingchuan
    Li, Lian-Sheng
    Hansen, Rasmus
    Peters, Ulf
    Guo, Xin
    Chen, Yuching
    Babbar, Anjali
    Firdaus, Sarah J.
    Darjania, Levan
    Feng, Jun
    Chen, Jeffrey H.
    Li, Shuangwei
    Li, Shisheng
    Long, Yun O.
    Thach, Carol
    Liu, Yuan
    Zarieh, Ata
    Ely, Tess
    Kucharski, Jeff M.
    Kessler, Linda V.
    Wu, Tao
    Yu, Ke
    Wang, Yi
    Yao, Yvonne
    Deng, Xiaohu
    Zarrinkar, Patrick P.
    Brehmer, Dirk
    Dhanak, Dashyant
    Lorenzi, Matthew V.
    Hu-Lowe, Dana
    Patricelli, Matthew P.
    Ren, Pingda
    Liu, Yi
    [J]. CELL, 2018, 172 (03) : 578 - +
  • [10] Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies
    Jordan, Emmet J.
    Kim, Hyunjae R.
    Arcila, Maria E.
    Barron, David
    Chakravarty, Debyani
    Gao, JianJiong
    Chang, Matthew T.
    Ni, Andy
    Kundra, Ritika
    Jonsson, Philip
    Jayakumaran, Gowtham
    Gao, Sizhi Paul
    Johnsen, Hannah C.
    Hanrahan, Aphrothiti J.
    Zehir, Ahmet
    Rekhtman, Natasha
    Ginsberg, Michelle S.
    Li, Bob T.
    Yu, Helena A.
    Paik, Paul K.
    Drilon, Alexander
    Hellmann, Matthew D.
    Reales, Dalicia N.
    Benayed, Ryma
    Rusch, Valerie W.
    Kris, Mark G.
    Chaft, Jamie E.
    Baselga, Jose
    Taylor, Barry S.
    Schultz, Nikolaus
    Rudin, Charles M.
    Hyman, David M.
    Berger, Michael F.
    Solit, David B.
    Ladanyi, Marc
    Riely, Gregory J.
    [J]. CANCER DISCOVERY, 2017, 7 (06) : 596 - 609