Effect of previous vaccination with pneumococcal conjugate vaccine on pneumococcal polysaccharide vaccine antibody responses

被引:10
作者
Schaballie, H. [1 ,2 ]
Wuyts, G. [2 ]
Dillaerts, D. [2 ]
Frans, G. [2 ,3 ]
Moens, L. [2 ]
Proesmans, M. [1 ]
Vermeulen, F. [1 ]
De Boeck, K. [1 ]
Meyts, I. [1 ,2 ]
Bossuyt, X. [2 ,3 ]
机构
[1] Univ Hosp Leuven, Dept Pediat, Leuven, Belgium
[2] KU Leuven Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium
[3] Univ Hosp Leuven, Dept Lab Med, Leuven, Belgium
关键词
pneumococcal conjugate vaccine; polysaccharide antibody deficiency; specific antibody deficiency; unconjugated pneumococcal polysaccharide vaccine; STREPTOCOCCUS-PNEUMONIAE VACCINE; RECURRENT INFECTIONS; CHILDREN; IMMUNOGENICITY; DIAGNOSIS; IMMUNODEFICIENCY; REACTOGENICITY; DEFICIENCY; AVIDITY;
D O I
10.1111/cei.12784
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
During the past 10 years, pneumococcal conjugate vaccine (PCV) has become part of the standard childhood vaccination programme. This may impact upon the diagnosis of polysaccharide antibody deficiency by measurement of anti-polysaccharide immunoglobulin (Ig)G after immunization with unconjugated pneumococcal polysaccharide vaccine (PPV). Indeed, contrary to PPV, PCV induces a T-dependent, more pronounced memory response. The antibody response to PPV was studied retrospectively in patients referred for suspected humoral immunodeficiency. The study population was divided into four subgroups based on age (2-5 years versus 10 years) and time tested (1998-2005 versus 2010-12). Only 2-5-year-old children tested in 2010-12 had been vaccinated with PCV prior to PPV. The PCV primed group showed higher antibody responses for PCV-PPV shared serotypes 4 and 18C than the unprimed groups. To a lesser extent, this was also found for non-PCV serotype 9N, but not for non-PCV serotypes 19A and 8. Furthermore, PCV-priming elicited a higher IgG2 response. In conclusion, previous PCV vaccination affects antibody response to PPV for shared serotypes, but can also influence antibody response to some non-PCV serotypes (9N). With increasing number of serotypes included in PCV, the diagnostic assessment for polysaccharide antibody deficiency requires careful selection of serotypes that are not influenced by prior PCV (e.g. serotype 8). Further research is needed to identify more serotypes that are not influenced.
引用
收藏
页码:180 / 189
页数:10
相关论文
共 36 条
[1]   AN IMMUNODEFICIENCY CHARACTERIZED BY IMPAIRED ANTIBODY-RESPONSES TO POLYSACCHARIDES [J].
AMBROSINO, DM ;
SIBER, GR ;
CHILMONCZYK, BA ;
JERNBERG, JB ;
FINBERG, RW .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (13) :790-793
[2]   Avidity of IgG for Streptococcus pneumoniae type 6B and 23F polysaccharides in infants primed with pneumococcal conjugates and boosted with polysaccharide or conjugate vaccines [J].
Anttila, M ;
Eskola, J ;
Åhman, H ;
Käyhty, H .
JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (06) :1614-1621
[3]   Differences in the avidity of antibodies evoked by four different pneumococcal conjugate vaccines in early childhood [J].
Anttila, M ;
Eskola, J ;
Åhman, H ;
Käyhty, H .
VACCINE, 1999, 17 (15-16) :1970-1977
[4]   Infants aged 12 months can mount adequate serotype-specific IgG responses to pneumococcal polysaccharide vaccine [J].
Balloch, Anne ;
Licciardi, Paul V. ;
Russell, Fiona M. ;
Mulholland, Edward K. ;
Tang, Mimi L. K. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 126 (02)
[5]   Vaccines in the assessment of patients for immune deficiency [J].
Ballow, Mark .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (01) :283-+
[6]   Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes [J].
Bentley, Stephen D. ;
Aanensen, David M. ;
Mavroidi, Angeliki ;
Saunders, David ;
Rabbinowitsch, Ester ;
Collins, Matthew ;
Donohoe, Kathy ;
Harris, David ;
Murphy, Lee ;
Quail, Michael A. ;
Samuel, Gabby ;
Skovsted, Ian C. ;
Kaltoft, Margit Staum ;
Barrell, Bart ;
Reeves, Peter R. ;
Parkhill, Julian ;
Spratt, Brian G. .
PLOS GENETICS, 2006, 2 (03) :262-269
[7]   Polysaccharide Responsiveness Is Not Biased by Prior Pneumococcal-Conjugate Vaccination [J].
Bernth-Jensen, Jens Magnus ;
Sogaard, Ole Schmeltz .
PLOS ONE, 2013, 8 (10)
[8]   Practice parameter for the diagnosis and management of primary immunodeficiency [J].
Bonilla, FA ;
Bernstein, IL ;
Khan, DA ;
Ballas, ZK ;
Chinen, J ;
Frank, MM ;
Kobrynski, LJ ;
Levinson, AI ;
Mazer, B ;
Nelson, RP ;
Orange, JS ;
Routes, JM ;
Shearer, WT ;
Sorensen, RU .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2005, 94 (05) :S1-S63
[9]   Laboratory diagnosis of specific antibody deficiency to pneumococcal capsular polysaccharide antigens by multiplexed bead assay [J].
Borgers, Heleen ;
Moens, Leen ;
Picard, Capucine ;
Jeurissen, Axel ;
Raes, Marc ;
Sauer, Kate ;
Proesmans, Marijke ;
De Boeck, Kris ;
Casanova, Jean-Laurent ;
Meyts, Isabelle ;
Bossuyt, Xavier .
CLINICAL IMMUNOLOGY, 2010, 134 (02) :198-205
[10]   Age-and serotype-dependent antibody response to pneumococcal polysaccharides [J].
Bossuyt, Xavier ;
Borgers, Heleen ;
Moens, Leen ;
Verbinnen, Bert ;
Meyts, Isabelle .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (04) :1079-1080