Phenytoin-induced toxic cholestatic hepatitis in a patient with skin lesions:: Case report

被引：9

作者：

Altuntas, Y ^{[1
]}

Öztürk, B ^{[1
]}

Erdem, L ^{[1
]}

Günes, G ^{[1
]}

Karul, S ^{[1
]}

Uçak, S ^{[1
]}

Sengül, A ^{[1
]}

机构：

[1] Sisli Etfal Educ & Res Hosp, Internal Med & Gastroenterol Clin, Istanbul, Turkey

来源：

SOUTHERN MEDICAL JOURNAL | 2003年 / 96卷 / 02期

关键词：

D O I：

10.1097/01.SMJ.0000051269.23361.4A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Phenytoin is a highly effective and widely prescribed anticonvulsant agent, but it can be associated with dose-related side effects and hypersensitivity reactions. We present a case of phenytoin-induced cholestatic hepatotoxicity in a 47-year-old woman who had exfoliative dermatitis, an increase in liver enzymes with a cholestatic pattern, and eosinophilia after 25 days of phenytoin therapy. The diagnostic workup showed no other possible causes, and the results of a percutaneous liver biopsy were consistent with drug-induced toxic hepatitis. Within 3 weeks after discontinuing phenytoin therapy, her liver function tests returned to normal values.

引用

页码：201 / 203

页数：3

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