A new lumazine peptide penilumamide E from the fungus Aspergillus terreus

被引：24

作者：

Chaiyosang, Boonyanoot ^{[1
,2
]}

Kanokmedhakul, Kwanjai ^{[1
,2
]}

Boonmak, Jaursup ^{[1
,3
]}

Youngme, Sujittra ^{[1
,3
]}

Kukongviriyapan, Veerapol ^{[4
]}

Soytong, Kasem ^{[5
]}

Kanokmedhakul, Somdej ^{[1
,2
]}

机构：

[1] Khon Kaen Univ, Dept Chem, Fac Sci, Khon Kaen, Thailand

[2] Khon Kaen Univ, Ctr Excellence Innovat Chem, Nat Prod Res Unit, Khon Kaen, Thailand

[3] Khon Kaen Univ, Ctr Excellence Innovat Chem, Mat Chem Res Ctr, Khon Kaen, Thailand

[4] Khon Kaen Univ, Dept Pharmacol, Fac Med, Khon Kaen, Thailand

[5] King Mongkuts Inst Technol Ladkrabang, Fac Agr Technol, Dept Plant Prod Technol, Bangkok, Thailand

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 09期

关键词：

Aspergillus terreus; lumazine peptide; penilumamide E; epi-aszonalenin A; butyrolactone; antimalarial; BUTYROLACTONES;

D O I：

10.1080/14786419.2015.1101107

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2-14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values of 2.83g/mL. Compounds 4 and 6 showed weak cytotoxicity against cholangiocarcinoma (CCA) cell lines. In addition, 4 and 11 exhibited weak cytotoxicity against human hepatoma cell line.

引用

页码：1017 / 1024

页数：8

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