Advances in Cancer Treatment by Targeting the Neddylation Pathway

被引：30
作者：
Gai, Wenbin [1 ,2 ]
Peng, Zhiqiang [3 ]
Liu, Cui Hua [4 ]
Zhang, Lingqiang [1 ,2 ,3 ,5 ]
Jiang, Hong [1 ,2 ]
机构：
[1] Qingdao Univ, Shandong Prov Key Lab Pathogenesis & Prevent Neur, Sch Basic Med, Dept Physiol,Med Coll, Qingdao, Peoples R China
[2] Qingdao Univ, Sch Basic Med, Med Coll, State Key Disciplines Physiol, Qingdao, Peoples R China
[3] Beijing Inst Lifeom, Natl Ctr Prot Sci Beijing, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing, Peoples R China
[4] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China
[5] Peixian Peoples Hosp, Xuzhou, Jiangsu, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
基金：
中国国家自然科学基金;
关键词：
developmental down-regulation protein 8 (NEDD8); neddylation; MLN4924; treatment; cancer;
D O I：
10.3389/fcell.2021.653882
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Developmental down-regulation protein 8 (NEDD8), expressed by neural progenitors, is a ubiquitin-like protein that conjugates to and regulates the biological function of its substrates. The main target of NEDD8 is cullin-RING E3 ligases. Upregulation of the neddylation pathway is closely associated with the progression of various tumors, and MLN4924, which inhibits NEDD8-activating enzyme (NAE), is a promising new antitumor compound for combination therapy. Here, we summarize the latest progress in anticancer strategies targeting the neddylation pathway and their combined applications, providing a theoretical reference for developing antitumor drugs and combination therapies.
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页数：10
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