Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels

被引：150

作者：

Douguet, Dominique ^{[1
]}

Honore, Eric ^{[1
]}

机构：

[1] Univ Cote Azur, CNRS, INSERM, Inst Pharmacol Mol & Cellulaire,Labex ICST, Valbonne, France

来源：

CELL | 2019年 / 179卷 / 02期

关键词：

MECHANOTRANSDUCTION CHANNEL; HAIR-CELLS; MECHANOSENSITIVE CHANNEL; BLOOD-PRESSURE; PIEZO2; TREK-1; MECHANISM; TRAAK; TOUCH; TMC1;

D O I：

10.1016/j.cell.2019.08.049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conversion of force into an electrical cellular signal is mediated by the opening of different types of mechansensitive ion channels (MSCs) including TREK/TRAAK K-2P channels, Piezo1/2, TMEM63/OSCA, and TMC1/2. Mechanoelectrical transduction plays a key role in hearing, balance, touch, and proprioception and is also implicated in the autonomic regulation of blood pressure and breathing. Thus, dysfunction of MSCs is associated with a variety of inherited and acquired disease states. Significant progress has recently been made in identifying these channels, solving 'heir structure, and understanding the gating of both hyperpolarizing and depolarizing MSCs. Besides prototypical activation by membrane tension, additional gating mechanisms involving channel curvature and/or tethered elements are at play.

引用

页码：340 / 354

页数：15

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