Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels

被引：150

作者：

Douguet, Dominique ^{[1
]}

Honore, Eric ^{[1
]}

机构：

[1] Univ Cote Azur, CNRS, INSERM, Inst Pharmacol Mol & Cellulaire,Labex ICST, Valbonne, France

来源：

CELL | 2019年 / 179卷 / 02期

关键词：

MECHANOTRANSDUCTION CHANNEL; HAIR-CELLS; MECHANOSENSITIVE CHANNEL; BLOOD-PRESSURE; PIEZO2; TREK-1; MECHANISM; TRAAK; TOUCH; TMC1;

D O I：

10.1016/j.cell.2019.08.049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conversion of force into an electrical cellular signal is mediated by the opening of different types of mechansensitive ion channels (MSCs) including TREK/TRAAK K-2P channels, Piezo1/2, TMEM63/OSCA, and TMC1/2. Mechanoelectrical transduction plays a key role in hearing, balance, touch, and proprioception and is also implicated in the autonomic regulation of blood pressure and breathing. Thus, dysfunction of MSCs is associated with a variety of inherited and acquired disease states. Significant progress has recently been made in identifying these channels, solving 'heir structure, and understanding the gating of both hyperpolarizing and depolarizing MSCs. Besides prototypical activation by membrane tension, additional gating mechanisms involving channel curvature and/or tethered elements are at play.

引用

页码：340 / 354

页数：15

共 111 条

[1] Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels [J].

Albuisson, Juliette ;

Murthy, Swetha E. ;

Bandell, Michael ;

Coste, Bertrand ;

Louis-dit-Picard, Helene ;

Mathur, Jayanti ;

Feneant-Thibault, Madeleine ;

Tertian, Gerard ;

de Jaureguiberry, Jean-Pierre ;

Syfuss, Pierre-Yves ;

Cahalan, Stuart ;

Garcon, Loic ;

Toutain, Fabienne ;

Rohrlich, Pierre Simon ;

Delaunay, Jean ;

Picard, Veronique ;

Jeunemaitre, Xavier ;

Patapoutian, Ardem .

NATURE COMMUNICATIONS, 2013, 4

[2] TREK-1, a K+ channel involved in polymodal pain perception [J].

Alloui, Abdelkrim ;

Zimmermann, Katharina ;

Mamet, Julien ;

Duprat, Fabrice ;

Noel, Jacques ;

Chemin, Jean ;

Guy, Nicolas ;

Blondeau, Nicolas ;

Voilley, Nicolas ;

Rubat-Coudert, Catherine ;

Borsotto, Marc ;

Romey, Georges ;

Heurteaux, Catherine ;

Reeh, Peter ;

Eschalier, Alain ;

Lazdunski, Michel .

EMBO JOURNAL, 2006, 25 (11) :2368-2376

[3] TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels [J].

Anderson, Evan O. ;

Schneider, Eve R. ;

Matson, Jon D. ;

Gracheva, Elena O. ;

Bagriantsev, Sviatoslav N. .

CELL REPORTS, 2018, 23 (03) :701-708

[4] Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel [J].

Aryal, Prafulla ;

Jarerattanachat, Viwan ;

Clausen, Michael V. ;

Schewe, Marcus ;

McClenaghan, Conor ;

Argent, Liam ;

Conrad, Linus J. ;

Dong, Yin Y. ;

Pike, Ashley C. W. ;

Carpenter, Elisabeth P. ;

Baukrowitz, Thomas ;

Sansom, Mark S. P. ;

Tucker, Stephen J. .

STRUCTURE, 2017, 25 (05) :708-+

[5] Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1 [J].

Bae, Chilman ;

Gnanasambandam, Radhakrishnan ;

Nicolai, Chris ;

Sachs, Frederick ;

Gottlieb, Philip A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (12) :E1162-E1168

[6] Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains [J].

Bagriantsev, Sviatoslav N. ;

Clark, Kimberly A. ;

Minor, Daniel L., Jr. .

EMBO JOURNAL, 2012, 31 (15) :3297-3308

[7] Multiple modalities converge on a common gate to control K2P channel function [J].

Bagriantsev, Sviatoslav N. ;

Peyronnet, Remi ;

Clark, Kimberly A. ;

Honore, Eric ;

Minor, Daniel L., Jr. .

EMBO JOURNAL, 2011, 30 (17) :3594-3606

[8] Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins [J].

Ballesteros, Angela ;

Fenollar-Ferrer, Cristina ;

Swartz, Kenton Jon .

ELIFE, 2018, 7

[9] Mutations in KCNK4 that Affect Gating Cause a Recognizable Neurodevelopmental Syndrome [J].

Bauer, Christiane K. ;

Calligari, Paolo ;

Radio, Francesca Clementina ;

Caputo, Viviana ;

Dentici, Maria Lisa ;

Falah, Nadia ;

High, Frances ;

Pantaleoni, Francesca ;

Barresi, Sabina ;

Ciolfi, Andrea ;

Pizzi, Simone ;

Bruselles, Alessandro ;

Person, Richard ;

Richards, Sarah ;

Cho, Megan T. ;

Sepulveda, Daniela J. Claps ;

Pro, Stefano ;

Battini, Roberta ;

Zampino, Giuseppe ;

Digilio, Maria Cristina ;

Bocchinfuso, Gianfranco ;

Dallapiccola, Bruno ;

Stella, Lorenzo ;

Tartaglia, Marco .

AMERICAN JOURNAL OF HUMAN GENETICS, 2018, 103 (04) :621-630

[10] Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea [J].

Beurg, Maryline ;

Cui, Runjia ;

Goldring, Adam C. ;

Ebrahim, Seham ;

Fettiplace, Robert ;

Kachar, Bechara .

NATURE COMMUNICATIONS, 2018, 9

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