Structural Determinants of Yeast Protein-Protein Interaction Interface Evolution at the Residue Level

被引:1
作者
Pollet, Leah [1 ]
Lambourne, Luke [2 ,3 ,4 ,5 ]
Xia, Yu [1 ,5 ]
机构
[1] McGill Univ, Fac Engn, Dept Bioengn, Montreal, PQ, Canada
[2] Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA USA
[3] Harvard Med Sch, Blavatnik Inst, Dept Genet, Boston, MA USA
[4] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA USA
[5] Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA
关键词
PPIs; protein evolution; protein structure; S; cerevisiae; yeast; SOLVENT ACCESSIBILITY; SEQUENCE; CONSERVATION; RECOGNITION; PRINCIPLES; NETWORKS; CONTEXT; SEARCH; DESIGN; MODEL;
D O I
10.1016/j.jmb.2022.167750
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interfaces of contact between proteins play important roles in determining the proper structure and func-tion of protein-protein interactions (PPIs). Therefore, to fully understand PPIs, we need to better under-stand the evolutionary design principles of PPI interfaces. Previous studies have uncovered that interfacial sites are more evolutionarily conserved than other surface protein sites. Yet, little is known about the nature and relative importance of evolutionary constraints in PPI interfaces. Here, we explore constraints imposed by the structure of the microenvironment surrounding interfacial residues on residue evolutionary rate using a large dataset of over 700 structural models of baker's yeast PPIs. We find that interfacial residues are, on average, systematically more conserved than all other residues with a similar degree of total burial as measured by relative solvent accessibility (RSA). Besides, we find that RSA of the residue when the PPI is formed is a better predictor of interfacial residue evolutionary rate than RSA in the monomer state. Furthermore, we investigate four structure-based measures of residue interfacial involve-ment, including change in RSA upon binding (DRSA), number of residue-residue contacts across the interface, and distance from the center or the periphery of the interface. Integrated modeling for evolution-ary rate prediction in interfaces shows that DRSA plays a dominant role among the four measures of inter-facial involvement, with minor, but independent contributions from other measures. These results yield insight into the evolutionary design of interfaces, improving our understanding of the role that structure plays in the molecular evolution of PPIs at the residue level. (c) 2022 Elsevier Ltd. All rights reserved.
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页数:18
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