The secretome of mesenchymal stem cells and oxidative stress: challenges and opportunities in cell-free regenerative medicine

被引:30
作者
Rahimi, Bahareh [1 ,4 ]
Panahi, Mohammad [2 ,3 ]
Saraygord-Afshari, Neda [4 ]
Taheri, Neda [5 ]
Bilici, Merve [6 ]
Jafari, Davod [4 ]
Alizadeh, Effat [7 ,8 ]
机构
[1] Iran Univ Med Sci, Student Res Comm, Tehran, Iran
[2] Tabriz Univ Med Sci, Dept Med Biotechnol, Fac Adv Med Sci, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Adv Med Sci, Student Res Comm, Tabriz, Iran
[4] Iran Univ Med Sci, Fac Allied Med Sci, Dept Med Biotechnol, Tehran, Iran
[5] Univ Esfahan, Dept Plant & Anim Biol, Esfahan, Iran
[6] Ege Univ, Dept Biochem, Fac Sci, Izmir, Turkey
[7] Tabriz Univ Med Sci, Fac Adv Med Sci, Drug Appl Res Ctr, Golgasht St, Tabriz 516615731, Iran
[8] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Biotechnol, Golgasht St, Tabriz 516615731, Iran
关键词
Oxidative stress; Mesenchymal stem cells; Exosomes; Regenerative medicine; Secretome; STROMAL CELLS; CONDITIONED MEDIA; IFATS COLLECTION; GROWTH-FACTOR; BONE-MARROW; ANGIOGENESIS; MECHANISMS; EXPRESSION; DEATH; DIFFERENTIATION;
D O I
10.1007/s11033-021-06360-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Over the last decade, mesenchymal stem cells (MSCs) have been considered a suitable source for cell-based therapy, especially in regenerative medicine. First, the efficacy and functions of MSCs in clinical applications have been attributed to their differentiation ability, called homing and differentiation. However, it has recently been confirmed that MSCs mostly exert their therapeutic effects through soluble paracrine bioactive factors and extracellular vesicles, especially secretome. These secreted components play critical roles in modulating immune responses, improving the survival, and increasing the regeneration of damaged tissues. The secretome content of MSCs is variable under different conditions. Oxidative stress (OS) is one of these conditions that is highly important in MSC therapy and regenerative medicine. High levels of reactive oxygen species (ROS) are produced during isolation, cell culture, and transplantation lead to OS, which induces cell death and apoptosis and limits the efficacy of their regeneration capability. In turn, the preconditioning of MSCs in OS conditions contributes to the secretion of several proteins, cytokines, growth factors, and exosomes, which can improve the antioxidant potential of MSCs against OS. This potential of MSC secretome has turned it into a new promising cell-free tissue regeneration strategy. This review provides a view of MSC secretome under OS conditions, focusing on different secretome contents of MSCs and thier possible therapeutic potential against cell therapy.
引用
收藏
页码:5607 / 5619
页数:13
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