Chemoselective Aza-Michael addition of indoles with 2-arylidenemalononitriles

被引：5
作者：
Cheng, Ya [1 ]
Li, Zheng [1 ]
机构：
[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou, Gansu, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2020年 / 50卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Aza-Michael addition; 2-arylidenemalononitrile; atom economy; chemoselectivity; indole; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; DERIVATIVES; CATALYST;
D O I：
10.1080/00397911.2019.1708947
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The selective aza-Michael addition at N1-position of indoles to 2-arylidenemalononitriles in the presence of potassium hydroxide is described. The salient features of this protocol are no transition-metal catalysts, mild conditions, high chemoselectivity, high atom economy, high yield and simple work-up procedures.
引用
收藏
页码：571 / 579
页数：9
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