EV71: An emerging infectious disease vaccine target in the Far East?

被引：115
作者：
Xu, Juan [2 ,3 ,4 ]
Qian, Yuan [5 ]
Wang, Shixia [1 ,3 ]
Serrano, Jill M. Grimes [1 ]
Li, Wei [6 ]
Huang, Zuhu [2 ,3 ]
Lu, Shan [1 ,2 ,3 ]
机构：
[1] Univ Massachusetts, Sch Med, Dept Med, Lab Nucle Acid Vaccines, Worcester, MA 01605 USA
[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Infect Dis, Jiangsu Key Lab Infect Dis, Nanjing 210029, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, China US Vaccine Res Ctr, Nanjing 210029, Peoples R China
[4] Nanjing Med Univ, Dept Microbiol & Immunol, Nanjing 210030, Peoples R China
[5] Capital Inst Pediat, Beijing 100020, Peoples R China
[6] Technol & Achievement Transformat Ctr Taizhou Med, Taizhou 225300, Peoples R China
来源：
VACCINE | 2010年 / 28卷 / 20期
关键词：
Hand; foot; and mouth disease; EV71; Emerging infectious disease; Vaccine development; ENTEROVIRUS; 71; INFECTION; POLIOMYELITIS-LIKE DISEASE; CAPSID PROTEIN VP1; REPUBLIC-OF-CHINA; MOUTH-DISEASE; MOLECULAR EPIDEMIOLOGY; LETHAL ENTEROVIRUS-71; NEUTRALIZING ANTIBODIES; CYNOMOLGUS MONKEYS; GENETIC-ANALYSIS;
D O I：
10.1016/j.vaccine.2010.03.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hand, foot, and mouth disease (HFMD) is a common viral illness in infants and children caused by viruses that belong to the enterovirus genus of the picornavirus family. Although most HFMD do not result in serious complications, outbreaks of HFMD caused by enterovirus 71 (EV71) can present with a high rate of neurological complications, including meningoencephalitis, pulmonary complications, and possibly death. HFMD caused by EV71 has become a major emerging infectious disease in Asia and the highly pathogenic potential of EV71 clearly requires the attention of world medical community. Although vaccine development for EV71 is active and ongoing in Asian countries, a greater joint effort is needed for vaccine researchers and developers in both developed and developing countries to produce a safe and effective EV71 vaccine. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3516 / 3521
页数：6
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