Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus

被引：81

作者：

Cenizal, Mary Jo

Skiest, Daniel

Luber, Samuel

Bedimo, Roger

Davis, Pat

Fox, Patrick

Delaney, Kathleen

Hardy, R. Doug

机构：

[1] SW Texas Univ, Med Ctr, Dallas, TX USA

[2] VA N Texas Hlth Care Syst, Dallas, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 07期

关键词：

D O I：

10.1128/AAC.00206-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim-sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.

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收藏

页码：2628 / 2630

页数：3

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