Analysis of the mechanical properties of chromosomes in air and liquid by AFM

被引：2
作者：
Wang, Bowei [1 ,2 ]
Yang, Fan [1 ,2 ]
Dong, Jianjun [1 ,2 ]
Li, Jiani [1 ,2 ]
Wang, Ying [1 ,2 ]
Qu, Kaige [1 ,2 ]
Wei, Huimiao [3 ]
Wang, Zuobin [1 ,2 ,4 ,5 ]
机构：
[1] Changchun Univ Sci & Technol, Key Lab Cross Scale Micro & Nano Mfg, Minist Educ, Changchun 130022, Peoples R China
[2] Changchun Univ Sci & Technol, Int Res Ctr Nano Handling & Mfg China, Changchun 130022, Peoples R China
[3] Changli Nano Biotechnol Ltd, Changchun 130022, Peoples R China
[4] Univ Bedfordshire, JR3CN, Luton LU1 3JU, Beds, England
[5] Univ Bedfordshire, IRAC, Luton LU1 3JU, Beds, England
来源：
2021 IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (3M-NANO) | 2021年
基金：
国家重点研发计划;
关键词：
atomic force microscopy; chromosome; morphology; mechanical properties; ATOMIC-FORCE MICROSCOPY; CHROMATIN;
D O I：
10.1109/3M-NANO49087.2021.9599772
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Chromosomes contain all the genomic information thus making the study of chromosomes practical and significant. Herein, the morphologies of chromosomes prepared with different methods were monitored by atomic force microscopy (AFM). Moreover, the mechanical properties of chromosomes in air and liquid were investigated quantitatively through AFM-based force spectroscopy. The differences of chromosome morphologies and mechanical properties caused by sample preparations indicated that the chromosome characterization in liquid was more meaningful to rep cal the physiological characteristics of chromosomes.
引用
收藏
页码：43 / 46
页数：4
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