Intravenous Voriconazole after Toxic Oral Administration

被引：8

作者：

Alffenaar, J. W. C. ^{[1
]}

van Assen, S. ^{[2
]}

de Monchy, J. G. R. ^{[3
]}

Uges, D. R. A. ^{[1
]}

Kosterink, J. G. W. ^{[1
]}

van der Werf, T. S. ^{[2
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Hosp & Clin Pharm, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Infect Dis, NL-9700 RB Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Allergol, NL-9700 RB Groningen, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 06期

关键词：

HEPATOTOXICITY;

D O I：

10.1128/AAC.01193-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a male patient with rhinocerebral invasive aspergillosis, prolonged high-dosage oral administration of voriconazole led to hepatotoxicity combined with a severe cutaneous reaction while intravenous administration in the same patient did not. High concentrations in the portal blood precipitate liver enzyme abnormalities, and therefore, oral administration of voriconazole may have a hepatotoxicity profile different from that of intravenous (i.v.) administration. Intravenously administered voriconazole might still be an option after oral-voriconazole-induced toxicity has resolved.

引用

页码：2741 / 2742

页数：2

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