Human mucosal-associated invariant T cells respond to Mucorales species in a MR1-dependent manner

被引：2
|
作者：
Boettcher, Sarah [1 ,2 ]
Hartung, Susann [1 ,2 ]
Meyer, Florian [3 ]
Rummler, Silke [4 ]
Voigt, Kerstin [5 ,6 ]
Walther, Grit [6 ]
Hochhaus, Andreas [1 ]
Von Lilienfeld-Toal, Marie [1 ,2 ,6 ]
Jahreis, Susanne [1 ,2 ]
机构：
[1] Univ Klinikum Jena, Abt Hamatol & Internist Onkol, Klin Innere Med 2, Jena, Germany
[2] Leibniz Inst Nat Prod Res & Infect Biol, Infect Hematol & Oncol, Jena, Germany
[3] Leibniz Inst Nat Prod Res & Infect Biol, Transfer Grp Antiinfect, Jena, Germany
[4] Univ Klinikum Jena, Inst Transfus Med, Jena, Germany
[5] Leibniz Inst Nat Prod Res & Infect Biol, Jena Microbial Resource Collect, Jena, Germany
[6] Leibniz Inst Nat Prod Res & Infect Biol, Natl Reference Ctr Invas Fungal Infect NRZMyk, Jena, Germany
来源：
MEDICAL MYCOLOGY | 2021年 / 59卷 / 05期
关键词：
MAIT cell; mucorales; MR1; moulds; riboflavin; VITAMIN-B METABOLITES; MAIT CELLS; ACTIVATION; SUBSET;
D O I：
10.1093/mmy/myaa103
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Activation of mucosal-associated invariant T cells (MAIT cells) by certain bacteria, viruses, and yeast is well studied, but the activation potential of filamentous moulds from the order Mucorales is not known. Here, we show a rapid response of human MAIT cells against the Mucorales species Mucor circinelloides, Rhizopus arrhizus, and Rhizopus microsporus. This activation included upregulation of CD69 and degranulation marked by increased CD107a expression, while intracellular perforin and granzyme A expression were reduced. Furthermore, blocking of the antigen-presenting molecule major histocompatibility complex class I-related abrogated MAIT cell activation demonstrating a T cell receptor-dependent stimulation by Mucorales.
引用
收藏
页码：505 / 509
页数：5
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