Highway to the inner nuclear membrane: rules for the road

被引：150

作者：

Lusk, C. Patrick ^{[1
]}

Blobel, Gunter ^{[1
]}

King, Megan C. ^{[1
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, Cell Biol Lab, New York, NY 10021 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 05期

关键词：

D O I：

10.1038/nrm2165

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by diffusion. Although these principles have long described the nuclear import of soluble proteins, recent evidence indicates that they also apply to the import of integral inner nuclear membrane proteins. Here we develop a set of rules that might govern the transport of proteins to the inner nuclear membrane.

引用

页码：414 / 420

页数：7

共 54 条

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