Iron(III)/TEMPO-Catalyzed Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles by Oxidative Cyclization under Mild Conditions

被引：39
|
作者：
Zhang, Guofu [1 ]
Yu, Yidong [1 ]
Zhao, Yiyong [1 ]
Xie, Xiaoqiang [1 ]
Ding, Chengrong [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China
来源：
SYNLETT | 2017年 / 28卷 / 11期
基金：
中国国家自然科学基金;
关键词：
oxadiazoles; iron catalysis; cyclization; oxidation; aroyl hydrazones; ONE-POT SYNTHESIS; N-ACYLHYDRAZONES; DERIVATIVES; ACIDS; OPTIMIZATION; OXADIAZOLES; HYDRAZONES; LIGANDS; DEVICES; ANALOGS;
D O I：
10.1055/s-0036-1588747
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient cationic Fe(III)/TEMPO-catalyzed oxidative cyclization of aroyl hydrazones has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives. The reaction offers a broad scope, good functional-group tolerance, and high yields under mild conditions in the presence of O-2.
引用
收藏
页码：1373 / 1377
页数：5
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