Iron(III)/TEMPO-Catalyzed Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles by Oxidative Cyclization under Mild Conditions

被引：40

作者：

Zhang, Guofu ^{[1
]}

Yu, Yidong ^{[1
]}

Zhao, Yiyong ^{[1
]}

Xie, Xiaoqiang ^{[1
]}

Ding, Chengrong ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

SYNLETT | 2017年 / 28卷 / 11期

基金：

中国国家自然科学基金;

关键词：

oxadiazoles; iron catalysis; cyclization; oxidation; aroyl hydrazones; ONE-POT SYNTHESIS; N-ACYLHYDRAZONES; DERIVATIVES; ACIDS; OPTIMIZATION; OXADIAZOLES; HYDRAZONES; LIGANDS; DEVICES; ANALOGS;

D O I：

10.1055/s-0036-1588747

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient cationic Fe(III)/TEMPO-catalyzed oxidative cyclization of aroyl hydrazones has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives. The reaction offers a broad scope, good functional-group tolerance, and high yields under mild conditions in the presence of O-2.

引用

页码：1373 / 1377

页数：5

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