Synthesis and antileishmanial profile of some novel terpenyl pyrimidines

被引：39
作者：
Pandey, S
Suryawanshi, SN [1 ]
Gupta, S
Srivastava, VML
机构：
[1] Cent Drug Res Inst, Div Med Chem, Lucknow, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 39卷 / 11期
关键词：
ionones; terpenyl pyrimidines; antileishmanial activity;
D O I：
10.1016/j.ejmech.2004.03.007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some novel terpenyl pyrimidine derivatives 2(a-d) and 6(a-b) have been synthesised from alpha/beta-ionone keteneacetals 1 and 5. The terpenyl pyrimidine 2e has been synthesised from P-ionone 3 in two steps in quantitative yield. The pyrimidine derivatives were screened for in-vivo antilesihmanial activity. The compounds 2d, 2e, 6a and 6b showed promising in-vivo antileishmanial activity. (C) 2004 Elsevier SAS. All rights reserved.
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收藏
页码：969 / 973
页数：5
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