Synthesis and antileishmanial profile of some novel terpenyl pyrimidines

被引：39

作者：

Pandey, S

Suryawanshi, SN ^{[1
]}

Gupta, S

Srivastava, VML

机构：

[1] Cent Drug Res Inst, Div Med Chem, Lucknow, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 39卷 / 11期

关键词：

ionones; terpenyl pyrimidines; antileishmanial activity;

D O I：

10.1016/j.ejmech.2004.03.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some novel terpenyl pyrimidine derivatives 2(a-d) and 6(a-b) have been synthesised from alpha/beta-ionone keteneacetals 1 and 5. The terpenyl pyrimidine 2e has been synthesised from P-ionone 3 in two steps in quantitative yield. The pyrimidine derivatives were screened for in-vivo antilesihmanial activity. The compounds 2d, 2e, 6a and 6b showed promising in-vivo antileishmanial activity. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：969 / 973

页数：5

共 21 条

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