Mathematical modeling of gonadotropin-releasing hormone signaling

被引：25

作者：

Pratap, Amitesh ^{[3
]}

Garner, Kathryn L. ^{[3
]}

Voliotis, Margaritis ^{[2
]}

Tsaneva-Atanasova, Krasimira ^{[1
,2
]}

McArdle, Craig A. ^{[3
]}

机构：

[1] Univ Exeter, Coll Engn Math & Phys Sci, Dept Math, Exeter EX4 4QF, Devon, England

[2] Univ Exeter, EPSRC Ctr Predict Modeling Healthcare, Exeter EX4 4QF, Devon, England

[3] Univ Bristol, Sch Clin Sci, Labs Integrat Neurosci & Endocrinol, Whitson St, Bristol BS1 3NY, Avon, England

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2017年 / 449卷 / 0C期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

GnRH; GPCR; NFAT; ERK; Mathematical modeling; Mutual information; ACTIVATED PROTEIN-KINASE; DYNAMIN-DEPENDENT INTERNALIZATION; PERIFUSED L-BETA-T2 CELLS; GNRH-PULSE-FREQUENCY; C-TERMINAL TAIL; FSH-BETA GENE; PITUITARY-CELLS; INFORMATION-TRANSFER; DIFFERENTIAL REGULATION; TRANSCRIPTION FACTORS;

D O I：

10.1016/j.mce.2016.08.022

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.

引用

页码：42 / 55

页数：14

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