AUC/MIC Pharmacodynamic Target Is Not a Good Predictor of Vancomycin Efficacy in Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis

被引：9

作者：

Castaneda, Ximena ^{[1
]}

Garcia-de-la-Maria, Cristina ^{[2
]}

Gasch, Oriol ^{[3
]}

Pericas, Juan M. ^{[2
]}

Armero, Yolanda ^{[2
]}

Soy, Dolors ^{[2
]}

Garcia-Gonzalez, Javier ^{[2
]}

Falces, Carlos ^{[2
]}

Ninot, Salvador ^{[2
]}

Almela, Manel ^{[2
,4
]}

Ambrosioni, Juan ^{[2
]}

Quintana, Eduardo ^{[2
]}

Vidal, Barbara ^{[2
]}

Fuster, David ^{[2
]}

Llopis, Jaume ^{[5
]}

Soto, Sara ^{[4
]}

Moreno, Asuncion ^{[2
]}

Marco, Francesc ^{[2
,4
]}

Miro, Jose M. ^{[2
]}

机构：

[1] Fdn Cardioinfantil, Inst Cardiol, Bogota, Colombia

[2] Univ Barcelona, IDIBAPS, Hosp Clin, Barcelona, Spain

[3] Autonomous Univ Barcelona, Hosp Parc Tauli Sabadell, Barcelona, Spain

[4] Barcelona Ctr Int Hlth Res CRESIB, Barcelona, Spain

[5] Univ Barcelona, Fac Biol, Dept Stat, Barcelona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 06期

关键词：

Staphylococcus aureus; MRSA; experimental endocarditis; vancomycin MIC; pharmacodynamic target; THERAPY; INFECTIONS; DAPTOMYCIN; BACTEREMIA; VALUES;

D O I：

10.1128/AAC.02486-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The aim of this in vivo study was to compare the efficacy of vancomycin at standard doses (VAN-SD) to that of VAN at adjusted doses (VAN-AD) in achieving a VAN area under the curve/MIC ratio (AUC/MIC) of >= 400 against three methicillin-resistant Staphylococcus aureus (MRSA) strains with different microdilution VAN MICs in an experimental endocarditis model. The valve vegetation bacterial counts after 48 h of VAN therapy were compared, and no differences were observed between the two treatment groups for any of the three strains tested. Overall, for VAN-SD and VAN-AD, the rates of sterile vegetations were 15/45 (33.3%) and 21/49 (42.8%) (P = 0.343), while the medians (interquartile ranges [IQRs]) for log(10) CFU/g of vegetation were 2 (0 to 6.9) and 2 (0 to 4.5) (P = 0.384), respectively. In conclusion, this VAN AUC/MIC pharmacodynamic target was not a good predictor of vancomycin efficacy in MRSA experimental endocarditis.

引用

页数：6

共 26 条

[1] Activity of glycopeptides against Staphylococcus aureus infection in a rabbit endocarditis model:: MICs do not predict in vivo efficacy
Asseray, N
Jacqueline, C
Le Mabecque, V
Batard, E
Bugnon, D
Potel, G
Caillon, J
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) : 857 - 859
[2] Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications A Scientific Statement for Healthcare Professionals From the American Heart Association
Baddour, Larry M.
Wilson, Walter R.
Bayer, Arnold S.
Fowler, Vance G., Jr.
Tleyjeh, Imad M.
Rybak, Michael J.
Barsic, Bruno
Lockhart, Peter B.
Gewitz, Michael H.
Levison, Matthew E.
Bolger, Ann F.
Steckelberg, James M.
Baltimore, Robert S.
Fink, Anne M.
O'Gara, Patrick
Taubert, Kathryn A.
[J]. CIRCULATION, 2015, 132 (15) : 1435 - 1486
[3] Synchrotron radiation infrared microspectroscopy to assess the activity of vancomycin against endocarditis vegetation bacteria
Batard, Eric
Jamme, Frederic
Montassier, Emmanuel
Bertrand, Dominique
Caillon, Jocelyne
Potel, Gilles
Dumas, Paul
[J]. JOURNAL OF MICROBIOLOGICAL METHODS, 2011, 85 (03) : 235 - 238
[4] Clinical and Laboratory Standarad Institute, 2012, M100S22 CLSI
[5] Bacterial biofilms: A common cause of persistent infections
Costerton, JW
Stewart, PS
Greenberg, EP
[J]. SCIENCE, 1999, 284 (5418) : 1318 - 1322
[6] EVALUATION OF ANTIBIOTIC DIFFUSION INTO CARDIAC VEGETATIONS BY QUANTITATIVE AUTORADIOGRAPHY
CREMIEUX, AC
MAZIERE, B
VALLOIS, JM
OTTAVIANI, M
AZANCOT, A
RAFFOUL, H
BOUVET, A
POCIDALO, JJ
CARBON, C
[J]. JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (05) : 938 - 944
[7] EFFECTS OF SUBINHIBITORY CONCENTRATIONS OF VANCOMYCIN OR CEFAMANDOLE ON BIOFILM PRODUCTION BY COAGULASE-NEGATIVE STAPHYLOCOCCI
DUNNE, WM
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (03) : 390 - 393
[8] DURACK DT, 1972, BRIT J EXP PATHOL, V53, P50
[9] Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus
Fowler, Vance G., Jr.
Boucher, Helen W.
Corey, G. Ralph
Abrutyn, Elias
Karchmer, Adolf W.
Rupp, Mark E.
Levine, Donald P.
Chambers, Henry F.
Tally, Francis P.
Vigliani, Gloria A.
Cabell, Christopher H.
Link, Arthur Stanley
DeMeyer, Ignace
Filler, Scott G.
Zervos, Marcus
Cook, Paul
Parsonnet, Jeffrey
Bernstein, Jack M.
Price, Connie Savor
Forrest, Graeme N.
Faetkenheuer, Gerd
Gareca, Marcelo
Rehm, Susan J.
Brodt, Hans Reinhardt
Tice, Alan
Cosgrove, Sara E.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (07) : 653 - 665
[10] Diagnosis and treatment of bacteremia and endocarditis due to Staphylococcus aureus. A clinical guideline from the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC)
Gudiol, Francesc
Maria Aguado, Jose
Almirante, Benito
Bouza, Emilio
Cercenado, Emilia
Angeles Dominguez, M.
Gasch, Oriol
Lora-Tamayo, Jaime
Miro, Jose M.
Palomar, Mercedes
Pascual, Alvaro
Pericas, Juan M.
Pujol, Miguel
Rodriguez-Bano, Jesus
Shaw, Evelyn
Soriano, Alex
Valles, Jordi
[J]. ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2015, 33 (09): : 625 - 625

← 1 2 3 →