Imaging genomics in cancer research: limitations and promises

被引：82

作者：

Bai, Harrison X. ^{[1
]}

Lee, Ashley M. ^{[1
]}

Yang, Li ^{[2
]}

Zhang, Paul ^{[3
]}

Davatzikos, Christos ^{[1
]}

Maris, John M. ^{[4
,5
,6
,7
]}

Diskin, Sharon J. ^{[4
,5
,6
,7
]}

机构：

[1] Hosp Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA

[2] Second Xiangya Hosp, Dept Neurol, Changsha, Hunan, Peoples R China

[3] Hosp Univ Penn, Dept Pathol & Lab Med, 3400 Spruce St, Philadelphia, PA 19104 USA

[4] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA

[5] Childrens Hosp Philadelphia, Ctr Childhood Canc Res, Philadelphia, PA 19104 USA

[6] Univ Penn, PerelmanSch Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[7] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

BRITISH JOURNAL OF RADIOLOGY | 2016年 / 89卷 / 1061期

关键词：

GROWTH-FACTOR RECEPTOR; MGMT PROMOTER METHYLATION; POSITRON-EMISSION-TOMOGRAPHY; RENAL-CELL-CARCINOMA; GENE-EXPRESSION PROGRAMS; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; MAGNETIC-RESONANCE; GLIOBLASTOMA-MULTIFORME; RADIOGENOMIC ANALYSIS;

D O I：

10.1259/bjr.20151030

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Recently, radiogenomics or imaging genomics has emerged as a novel high-throughput method of associating imaging features with genomic data. Radiogenomics has the potential to provide comprehensive intratumour, intertumour and peritumour information non-invasively. This review article summarizes the current state of radiogenomic research in tumour characterization, discusses some of its limitations and promises and projects its future directions. Semi-radiogenomic studies that relate specific gene expressions to imaging features will also be briefly reviewed.

引用

页数：17

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