Novel Approaches in Anaplastic Thyroid Cancer Therapy

被引：51

作者：

Hsu, Kun-Tai ^{[1
]}

Yu, Xiao-Min ^{[1
]}

Audhya, Anjon W. ^{[2
]}

Jaume, Juan C. ^{[3
]}

Lloyd, Ricardo V. ^{[4
]}

Miyamoto, Shigeri ^{[5
]}

Prolla, Tomas A. ^{[6
]}

Chen, Herbert ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Endocrine Surg Res Labs, Madison, WI 53792 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biomol Chem, Madison, WI 53792 USA

[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Endocrinol, Madison, WI 53792 USA

[4] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pathol & Lab Med, Madison, WI 53792 USA

[5] Univ Wisconsin, Sch Med & Publ Hlth, Dept Oncol, Madison, WI 53792 USA

[6] Univ Wisconsin, Sch Med & Publ Hlth, Dept Genet & Med Genet, Madison, WI 53792 USA

来源：

ONCOLOGIST | 2014年 / 19卷 / 11期

关键词：

Thyroid cancer; Anaplastic thyroid cancer; Notch; Histone deacetylase inhibitors; Kinase inhibitors; Clinical trials; SODIUM-IODIDE SYMPORTER; FACTOR-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; HISTONE DEACETYLASE INHIBITOR; FETAL CELL CARCINOGENESIS; TFG-ALK TRANSLOCATIONS; STEM-LIKE CELLS; PHASE-II TRIAL; FUSED GENE TFG; CARCINOMA-CELLS;

D O I：

10.1634/theoncologist.2014-0182

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anaplastic thyroid cancer (ATC), accounting for less than 2% of all thyroid cancer, is responsible for the majority of death from all thyroid malignancies and has a median survival of 6 months. The resistance of ATC to conventional thyroid cancer therapies, including radioiodine and thyroid-stimulating hormone suppression, contributes to the very poor prognosis of this malignancy. This review will cover several cellular signaling pathways and mechanisms, including RET/PTC, RAS, BRAF, Notch, p53, and histone deacetylase, which are identified to play roles in the transformation and dedifferentiation process, and therapies that target these pathways. Lastly, novel approaches and agents involving the Notch1 pathway, nuclear factor kappa B, Trk-fused gene, cancer stem-like cells, mitochondrial mutation, and tumor immune microenvironment are discussed. With a better understanding of the biological process and treatment modality, the hope is to improve ATC outcome in the future.

引用

页码：1148 / 1155

页数：8

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