Crosslinkable/functionalizable poly(2-oxazoline)based micelles

被引:4
作者
Rossegger, Elisabeth [1 ,2 ]
Pirolt, Franz [2 ]
Hoeppener, Stephanie [3 ]
Schubert, Ulrich S. [3 ,4 ]
Glatter, Otto [2 ]
Wiesbrock, Frank [1 ]
机构
[1] Polymer Competence Ctr Leoben GmbH, Roseggerstr 12, A-8700 Leoben, Austria
[2] Graz Univ Technol, Inst Chem & Technol Mat, NAWI Graz, Stremayrgasse 9, A-8010 Graz, Austria
[3] Friedrich Schiller Univ Jena, Lab Organ & Macromol Chem IOMC, Humboldtstr 10, D-07743 Jena, Germany
[4] Friedrich Schiller Univ Jena, JCSM, Philosophenweg 7, D-07743 Jena, Germany
关键词
Block copoly(2-oxazoline)s; Critical micellar concentration; Thiol-ene click reaction; Crosslinked micelles; Dynamic light scattering; Worm-shaped micelles; POLY(ETHYLENE GLYCOL); POLYMERIC MICELLES; BLOCK-COPOLYMERS; DRUG-DELIVERY; 2-ETHYL-2-OXAZOLINE; 2-NONYL-2-OXAZOLINE; CYTOTOXICITY; BEHAVIOR; DESIGN;
D O I
10.1016/j.eurpolymj.2019.109305
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Considering the pseudo-livingness of the cationic ring-opening polymerization of various 2-oxazoline monomers, micelles formed by amphiphilic diblock copoly(2-oxazoline)s are potential candidates for drug delivery. Copoly (2-oxazoline)s of the composition poly(2-ethyl-2-oxazoline)(100-n)-block-poly(2-dec-9'-enyl-2-oxazoline)(n) (n = 5, 10, 15) were found to form micelles in aqueous solution. The hydrophobic cores of these non-spherical micelles could be crosslinked by the thiol-ene reaction with glycol dimercapto acetate, the ester bonds of which can be cleaved by esterases. While the hydrodynamic radii of the non-crosslinked micelles increased if the hydrophobic block of poly(2-dec-9'-enyl-2-oxazoline) grew larger, the opposite trend could be observed for the crosslinked micelles. In the course of an oil uptake study, the hydrodynamic radii of the crosslinked as well as non-crosslinked micelles increased. In oil-filled micelles of poly(2-ethyl-2-oxazoline)(100-n)-block-poly(2-dec-9'-enyl-2-oxazoline)(n) (n = 5, 10, 15), the hydrodynamic radii of the non-crosslinked micelles were significantly larger in comparison with the crosslinked ones in case of n = 5 and 10, while the hydrodynamic radii of non-crosslinked and crosslinked micelles were of the same range in case of n = 15. The changes of diameter in micelles with polar molecules such as Zidovudine covalently attached to the hydrophobic core support the proposed antagonism of the inclusion of non-polar/polar molecules into the micelles' cores and the degree of crosslinking.
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页数:9
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