Control points in NKT-cell development

被引：226
|
作者：
Godfrey, Dale I. [1 ]
Berzins, Stuart P. [1 ]
机构：
[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia
来源：
NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 07期
基金：
英国医学研究理事会; 美国国家卫生研究院;
关键词：
D O I：
10.1038/nri2116
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD1d-dependent natural killer T (NKT) cells are a unique T-cell subset with the ability to regulate the immune system in response to a broad range of diseases. That low NKT-cell numbers are associated with many different disease states in mice and humans, combined with the fact that NKT-cell numbers vary widely between individuals, makes it crucial to understand how these cells develop and how their numbers are maintained. Here, we review the current state of knowledge of NKT-cell development and attempt to highlight the most important questions in this field.
引用
收藏
页码：505 / 518
页数：14
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