Myogenic potential of mouse primordial germ cells

被引：0
作者：
Klinger, FG
Scaldaferri, ML
Di Carlo, A
Baiocchi, M
Coletta, M
Cossu, G
De Felici, M
机构：
[1] Univ Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, I-00133 Rome, Italy
[2] Univ Roma La Sapienza, Dipartimento Embriol Med, I-00185 Rome, Italy
[3] Osped San Raffaele, Stem Cell Res Inst, Milan, Italy
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2003年 / 47卷 / 04期
关键词：
primordial germ cells; stem cells; myogenesis; transdifferentiation;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Primordial germ cells are the only stem cells that retain true developmental totipotency after gastrulation, express markers typical of totipotent/pluripotent status and are able both in vivo and in vitro to give rise to pluripotent stem cells as EC and EG cells. We have therefore explored the possibility of the trans-differentiation of mouse PGCs to a myogenic lineage by transplanting them directly or after in vitro culture into a regenerating muscle and by culturing them on monolayers of differentianting muscle cells. The results obtained suggest that mouse PGCs may trans-differentiate into myogenic cells, provided that their somatic environment is preserved. This occurs at an estimated frequency of 0.01%, which is no higher than that reported for stem cells of adult tissues.
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页码：303 / 305
页数：3
相关论文
共 25 条
[11]   Skeletal myogenic potential of human and mouse neural stem cells [J].
Galli, R ;
Borello, U ;
Gritti, A ;
Minasi, AG ;
Bjornson, C ;
Coletta, M ;
Mora, M ;
De Angelis, MGC ;
Fiocco, R ;
Cossu, G ;
Vescovi, AL .
NATURE NEUROSCIENCE, 2000, 3 (10) :986-991
[12]   Stem cells: is there a future in plastics? [J].
Goodell, MA .
CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (06) :662-665
[13]   MYOSIN LIGHT-CHAIN 3F REGULATORY SEQUENCES CONFER REGIONALIZED CARDIAC AND SKELETAL-MUSCLE EXPRESSION IN TRANSGENIC MICE [J].
KELLY, R ;
ALONSO, S ;
TAJBAKHSH, S ;
COSSU, G ;
BUCKINGHAM, M .
JOURNAL OF CELL BIOLOGY, 1995, 129 (02) :383-396
[14]   DERIVATION OF PLURIPOTENTIAL EMBRYONIC STEM-CELLS FROM MURINE PRIMORDIAL GERM-CELLS IN CULTURE [J].
MATSUI, Y ;
ZSEBO, K ;
HOGAN, BLM .
CELL, 1992, 70 (05) :841-847
[15]   Germ cells and pluripotent stem cells in the mouse [J].
McLaren, A ;
Durcova-Hills, G .
REPRODUCTION FERTILITY AND DEVELOPMENT, 2001, 13 (7-8) :661-664
[16]   Turning blood into brain:: Cells bearing neuronal antigens generated in vivo from bone marrow [J].
Mezey, É ;
Chandross, KJ ;
Harta, G ;
Maki, RA ;
McKercher, SR .
SCIENCE, 2000, 290 (5497) :1779-1782
[17]   Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 [J].
Nichols, J ;
Zevnik, B ;
Anastassiadis, K ;
Niwa, H ;
Klewe-Nebenius, D ;
Chambers, I ;
Schöler, H ;
Smith, A .
CELL, 1998, 95 (03) :379-391
[18]   PURIFICATION OF MOUSE PRIMORDIAL GERM-CELLS BY MINIMACS MAGNETIC SEPARATION SYSTEM [J].
PESCE, M ;
DEFELICI, M .
DEVELOPMENTAL BIOLOGY, 1995, 170 (02) :722-725
[19]   Bone marrow as a potential source of hepatic oval cells [J].
Petersen, BE ;
Bowen, WC ;
Patrene, KD ;
Mars, WM ;
Sullivan, AK ;
Murase, N ;
Boggs, SS ;
Greenberger, JS ;
Goff, JP .
SCIENCE, 1999, 284 (5417) :1168-1170
[20]   A molecular programme for the specification of germ cell fate in mice [J].
Saitou, M ;
Barton, SC ;
Surani, MA .
NATURE, 2002, 418 (6895) :293-300
123