Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration

被引：15
作者：
Azcoitia, I
Sierra, A
Veiga, S
Garcia-Segura, LM
机构：
[1] CSIC, Inst Cajal, E-28002 Madrid, Spain
[2] Univ Complutense, Fac Biol, Dept Biol Celular, E-28040 Madrid, Spain
来源：
JOURNAL OF NEURAL TRANSMISSION | 2005年 / 112卷 / 01期
关键词：
aging; aromatase; brain injury; estradiol; menopause; neurodegeneration; neuroprotection; peripheral type benzodiazepine receptor; progesterone; sex steroids; steroidogenic acute regulatory protein; testosterone;
D O I：
10.1007/s00702-004-0179-y
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Decreasing levels of gonadal steroids with aging are associated to an increas in cognitive, neurological and psychiatric disturbances. Estradiol is neuroprotective in animal models of neurodegeneration. However, the effects of hormonal replacement therapy on brain function in postmenopausal women are controversial. A possible alternative to hormonal replacement therapy is to increase local brain steroidogenesis, since experimental studies indicate that local estrogen formation in the brain is neuroprotective.
引用
收藏
页码：171 / 176
页数：6
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