Interaction between DNA and a novel ferrocenyl-containing ruthenium(II) polypyridyl complex

被引：0

作者：

Han, MJ

Wang, KZ ^{[1
]}

Lü, YY

Gao, LH

机构：

[1] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China

[2] Beijing Technol & Business Univ, Sch Chem & Environm Engn, Beijing 100037, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2004年 / 25卷 / 12期

关键词：

DNA; ruthenium( II ) complex; ferrocene;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel ruthenium polypyridyl complex of [Ru(bpy)(2)(FcIP)] (PF6)(2)(bpy = 2, 2'-bipyridine, FcIP=2-ferrocenyl-imidazo[4,5-f]-1, 10-phenanthroline) was synthesized and characterized by elementary analysis and H-1 NMR. The binding of the complex to calf thymus(ct) DNA was investigated with absorption and luminescence spectroscopy titrations, steady-state emission quenching, and viscosity measurements. The results suggest that the complex acted as a ct-DNA intercalator with an intrinsic binding constant of (2.0 +/- 0.4) X 10(5) L/mol in buffered 50 mmol/L NaCl.

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收藏

页码：2221 / 2223

页数：3

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