Interaction between DNA and a novel ferrocenyl-containing ruthenium(II) polypyridyl complex

被引:0
作者
Han, MJ
Wang, KZ [1 ]
Lü, YY
Gao, LH
机构
[1] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
[2] Beijing Technol & Business Univ, Sch Chem & Environm Engn, Beijing 100037, Peoples R China
来源
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2004年 / 25卷 / 12期
关键词
DNA; ruthenium( II ) complex; ferrocene;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel ruthenium polypyridyl complex of [Ru(bpy)(2)(FcIP)] (PF6)(2)(bpy = 2, 2'-bipyridine, FcIP=2-ferrocenyl-imidazo[4,5-f]-1, 10-phenanthroline) was synthesized and characterized by elementary analysis and H-1 NMR. The binding of the complex to calf thymus(ct) DNA was investigated with absorption and luminescence spectroscopy titrations, steady-state emission quenching, and viscosity measurements. The results suggest that the complex acted as a ct-DNA intercalator with an intrinsic binding constant of (2.0 +/- 0.4) X 10(5) L/mol in buffered 50 mmol/L NaCl.
引用
收藏
页码:2221 / 2223
页数:3
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