Episodic memory in progressive supranuclear palsy: a neuropsychological and neuroimaging study

被引：1

作者：

Macedo, Arthur Cassa ^{[1
]}

Caramelli, Paulo ^{[1
,2
,3
]}

Franca Resende, Elisa de Paula ^{[1
,2
]}

Mariano, Luciano Inacio ^{[1
,2
]}

Tumas, Vitor ^{[4
]}

Teixeira, Antonio Lucio ^{[5
,6
]}

Camargos, Sarah Teixeira ^{[2
,3
,7
]}

Cardoso, Francisco Eduardo Costa ^{[2
,3
,7
]}

de Souza, Leonardo Cruz ^{[1
,2
,3
]}

机构：

[1] Univ Fed Minas Gerais UFMG, Grp Neurol Cognit & Comportamento, Fac Med, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais UFMG, Programa Posgrad Neurociencias, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais UFMG, Dept Clin Med, Fac Med, Ave Prof Alfredo Balena 190-Sl 243, BR-30130100 Belo Horizonte, MG, Brazil

[4] Univ Sao Paulo, Ribeirao Preto, Brazil

[5] Santa Casa BH Ensino & Pesquisa, Ave Andradas 2-688, Belo Horizonte, MG, Brazil

[6] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, McGovern Med Sch, Neuropsychiatry Program, Houston, TX USA

[7] Univ Fed Minas Gerais UFMG, Ambulatorio Disturbios Movimento Hosp Clin, Belo Horizonte, MG, Brazil

来源：

NEUROLOGICAL SCIENCES | 2022年 / 43卷 / 09期

关键词：

Progressive supranuclear palsy; Episodic memory; Parkinsonism; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; COGNITIVE DEFICITS; PERFORMANCE; IMPAIRMENT; ATROPHY; TESTS;

D O I：

10.1007/s10072-022-06160-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Episodic memory impairment may occur in progressive supranuclear palsy (PSP). However, it remains uncertain whether this is due to executive dysfunction or to the involvement of brain areas responsible for memory. Objectives To investigate the specific brain regions underlying episodic memory impairment in PSP. Methods Twenty-one patients with PSP and 20 healthy controls underwent the Figure Memory Test (FMT) from the Brief Cognitive Screening Battery and brain MRI. We explored correlations between gray matter volumes and memory scores in PSP patients, adjusting for age and performance on the Frontal Assessment Battery. Results PSP patients performed worse than controls (p < 0.001) on delayed recall in the FMT. Delayed recall scores correlated to bilateral hippocampal and parahippocampal volumes in PSP patients. Conclusions Medial temporal structures may play a role in episodic memory impairment in PSP, suggesting that amnesia in PSP is not solely due to executive dysfunction.

引用

页码：5363 / 5368

页数：6

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