Role of Human Liver Microsomes in In Vitro Metabolism of Drugs-A Review

被引：146
作者：
Asha, Sepuri [1 ]
Vidyavathi, Maravajhala [1 ]
机构：
[1] Sri Padmavati Mahila Visvavidyalayam Womens Univ, Inst Pharmaceut Technol, Tirupati 517502, Andhra Pradesh, India
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2010年 / 160卷 / 06期
关键词：
Biotransformation; CYP450; Drug; Human liver microsomes; In vitro metabolism study; Metabolism; Metabolites; HUMAN CYTOCHROME-P450 ISOFORMS; ENZYME-KINETIC PARAMETERS; N-DEMETHYLATION; OXIDATIVE-METABOLISM; S-MEPHENYTOIN; STEREOSELECTIVE METABOLISM; CULTURED-HEPATOCYTES; P450; 2D6; TRIAZOLAM BIOTRANSFORMATION; HEPATIC BIOTRANSFORMATION;
D O I：
10.1007/s12010-009-8689-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Drug metabolism studies are essential and necessary during the evaluation of drugs. This review discusses the in vitro human liver models to estimate the drug metabolic fates in vivo. Different approaches are provided and emphasis is placed on the potential of human liver microsomes for drug metabolism and inhibition studies. The methodology for these studies using human liver microsomes, applications of human liver microsomes, and the drugs studied by human liver microsomes are listed. Human liver microsomes represent a critical experimental model for the evaluation of drug metabolites with a high probability of clinical success.
引用
收藏
页码：1699 / 1722
页数：24
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