Difluoromethyl phenyl sulfone, a difluoromethylidene equivalent: Use in the synthesis of 1,1-difluoro-1-alkenes

被引：72
作者：
Prakash, GKS
Hu, JB
Ying, W
Olah, GA
机构：
[1] Univ So Calif, Loker Hydrocarbon Res Inst, Los Angeles, CA 90089 USA
[2] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 39期
关键词：
alkenes; fluorination; elimination; fluorine; nucleophilic substitution;
D O I：
10.1002/anie.200460815
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A nucleophilic substitution-elimination reaction strategy in which difluoromethyl phenyl sulfone is used as a selective difluoromethylidene equivalent allows the facile synthesis of 1,1-difluoro-1-alkenes from primary alkyl halides (see scheme).
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收藏
页码：5203 / 5206
页数：4
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