Metastasis-related factors expressed in pT1 pN0 breast cancer: Assessment of recurrence risk

被引：16

作者：

Ogura, Shigeto

Ohdaira, Takeshi

Hozumi, Yasuo

Omoto, Yawara

Nagai, Hideo

机构：

[1] Department of General Surgery, Jichi Medical University, Tochigi

[2] Department of Pathology, Saitama Cancer Center, Saitama

[3] Department of General Surgery, Jichi Medical University, Shimotsuki, Tochigi 329-0498

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2007年 / 96卷 / 01期

关键词：

pT1 pN0 breast cancer; metastasis; recurrence; growth factor; proteinase; VEGF;

D O I：

10.1002/jso.20805

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: Previous reports have indicated that small breast cancers without lymph node metastasis present a favorable prognosis. However, 10-20% of patients with T1 N0 invasive ductal carcinoma experience recurrence and have a poor prognosis. The objective of this study was to examine whether certain metastasis-related factors are prognostic of cancer recurrence in such patients at risk for relapse. Methods: Nineteen patients with the carcinoma who had recurrence 1-15 years after margin-free resection were examined. The control group consisted of 20 patients with pT1 pN0 invasive ductal carcinoma who had no recurrence for ≥ 10 years after radical surgery. The two groups were compared with respect to clinical profiles, conventional neoplastic features, and immunohistochemical expressions of 16 metastasis-related factors. Results: No significant difference was found between the two groups in clinical profiles and conventional neoplastic features. However, six factors (MMP-2, MT1-MMP, T1MP-2, VEGF, cMET, and PCNA) were significantly expressed in the recurrence group against the control group. MMP-9 was significantly less expressed in the recurrence group. Of these factors, MMP-2, MT1-MMP, and VEGF showed the highest adjusted odds ratios. Conclusion: MMP family and growth factors may be promising predictors of recurrence risk of early stage breast cancer. © 2007 Wiley-Liss, Inc.

引用

页码：46 / 53

页数：8

共 65 条

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