The role of CRF receptor subtypes in stress-induced behavioural responses

被引：43

作者：

Smagin, GN ^{[1
]}

Dunn, AJ ^{[1
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Therapeut & Pharmacol, Shreveport, LA 71105 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 405卷 / 1-3期

关键词：

CRF (corticotropin-releasing factor); urocortin; (antagonist); CRF receptor; antisense; stress; behaviour;

D O I：

10.1016/S0014-2999(00)00553-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The actions of corticotropin-releasing factor (CRF) and CRF-related peptides in the brain and periphery are mediated through multiple receptors. Two CRF receptor subtypes that differ markedly in their pharmacological profiles and anatomical distribution have been identified and characterized. Important advances have been made in understanding CRF and its actions through the development of specific CRF receptor antagonists, application of antisense oligonucleotides, and the production of transgenic mice lacking functional CRF, receptors. This chapter describes recent findings with respect to CRF-related peptides and CRF receptors and their role in stress-induced behaviours. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：199 / 206

页数：8

共 76 条

[1]

Behan DP, 1996, MOL PSYCHIATR, V1, P265

[2] CORTICOTROPIN RELEASING-FACTOR (CRF) RECEPTOR ANTAGONIST BLOCKS ACTIVATING AND ANXIOGENIC ACTIONS OF CRF IN THE RAT [J].

BRITTON, KT ;

LEE, G ;

VALE, W ;

RIVIER, J ;

KOOB, GF .

BRAIN RESEARCH, 1986, 369 (1-2) :303-306

[3]

CHALMERS DT, 1995, J NEUROSCI, V15, P6340

[4] IDENTIFICATION OF A 7 TRANSMEMBRANE HELIX RECEPTOR FOR CORTICOTROPIN-RELEASING FACTOR AND SAUVAGINE IN MAMMALIAN BRAIN [J].

CHANG, CP ;

PEARSE, RV ;

OCONNELL, S ;

ROSENFELD, MG .

NEURON, 1993, 11 (06) :1187-1195

[5]

Chen C, 1996, J MED CHEM, V39, P4358

[6] EXPRESSION CLONING OF A HUMAN CORTICOTROPIN-RELEASING-FACTOR RECEPTOR [J].

CHEN, RP ;

LEWIS, KA ;

PERRIN, MH ;

VALE, WW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) :8967-8971

[7]

Curtis AL, 1997, J PHARMACOL EXP THER, V281, P163

[8] The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress [J].

Deak, T ;

Nguyen, KT ;

Ehrlich, AL ;

Watkins, LR ;

Spencer, RL ;

Maier, SF ;

Licinio, J ;

Wong, ML ;

Chrousos, GP ;

Webster, E ;

Gold, PW .

ENDOCRINOLOGY, 1999, 140 (01) :79-86

[9] Corticotropin-releasing factor receptors: Physiology, pharmacology, biochemistry and role in central nervous system and immune disorders [J].

DeSouza, EB .

PSYCHONEUROENDOCRINOLOGY, 1995, 20 (08) :789-819

[10] Cloning and characterization of human urocortin [J].

Donaldson, CJ ;

Sutton, SW ;

Perrin, MH ;

Corrigan, AZ ;

Lewis, KA ;

Rivier, JE ;

Vaughan, JM ;

Vale, WW .

ENDOCRINOLOGY, 1996, 137 (05) :2167-2170

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