Readily available biaryl P,N ligands for asymmetric catalysis

被引：322

作者：

Knöpfel, TF ^{[1
]}

Aschwanden, P ^{[1
]}

Ichikawa, T ^{[1
]}

Watanabe, T ^{[1
]}

Carreira, EM ^{[1
]}

机构：

[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 44期

关键词：

asymmetric catalysis; atropisomerism; heterocycles; hydroboration; P; N ligands;

D O I：

10.1002/anie.200461286

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short and modular synthesis of novel P,N ligands (pinap; see scheme; X = O or NH) is presented. A covalently bound chiral group allows the separation of the atropisomeric diastereomers, thus avoiding resolution involving chiral Pd-amine complexes. The utility of the ligands is demonstrated for three reactions catalyzed by different transition metals; in each case products are obtained with high enantiomeric excess (up to 99% ee).

引用

页码：5971 / 5973

页数：3

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