The role of M6A modification in the regulation of tumor-related lncRNAs

被引：67

作者：

Lan, Yufei ^{[1
]}

Liu, Boyang ^{[1
]}

Guo, Hongbo ^{[1
]}

机构：

[1] Southern Med Univ, Guangdong Prov Key Lab Brain Funct Repair & Regen, Neurosurg Inst Guangdong Prov,Zhujiang Hosp,Educ, Neurosurg Ctr,Natl Key Clin Specialty,Engn Techno, Guangzhou 510282, Peoples R China

来源：

MOLECULAR THERAPY NUCLEIC ACIDS | 2021年 / 24卷

基金：

中国国家自然科学基金;

关键词：

LONG NONCODING RNAS; MESSENGER-RNA; COLORECTAL-CANCER; COMPREHENSIVE ANALYSIS; THERAPEUTIC TARGET; PANCREATIC-CANCER; PROSTATE-CANCER; GENE-EXPRESSION; NUCLEAR-RNA; CELL-CYCLE;

D O I：

10.1016/j.omtn.2021.04.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

N-6-methyladenosine (m(6)A) is the most abundant modification in eukaryotic cells, and it regulates RNA transcription, processing, splicing, degradation, and translation. Long non-coding RNAs (lncRNAs), as transcriptional products with no or limited protein coding ability more than 200 nt in length, play an important role in epigenetic modification, mRNA transcription, splicing, stability, translation, and other biological functions. Extensive studies have shown that both m(6)A modification and lncRNAs are involved in the pathogenesis of various diseases, such as kinds of cancers, heart failure, Alzheimer's disease, periodontitis, human abdominal aortic aneurysm, and obesity. To date, m(6)A modification has been identified as an important biological function in enrichment and regulation of lncRNAs. In this review, we summarize the role of m(6)A modification in the regulation and function of tumor-related lncRNAs. Moreover, we discuss the potential applications and possible future directions in the field.

引用

页码：768 / 779

页数：12

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