Nanodevices for studying nano-pathophysiology

被引：22

作者：

Cabral, Horacio ^{[1
]}

Miyata, Kanjiro ^{[2
]}

Kishimura, Akihiro ^{[3
,4
]}

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138656, Japan

[2] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1130033, Japan

[3] Kyushu Univ, Ctr Mol Syst, Nishi Ku, Fukuoka 8190395, Japan

[4] Kyushu Univ, Fac Engn, Dept Appl Chem, Nishi Ku, Fukuoka 8190395, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2014年 / 74卷

关键词：

Nanomaterials; Polymeric self-assemblies; Theranostic nano-devices; MESOPOROUS SILICA NANOPARTICLES; BLOCK-COPOLYMER MICELLES; IRON-OXIDE NANOPARTICLES; POLYION COMPLEX VESICLES; DRUG-DELIVERY SYSTEMS; MULTIFUNCTIONAL POLYMERIC MICELLES; PEGYLATED LIPOSOMAL DOXORUBICIN; EFFICIENT GENE-TRANSFER; IN-VIVO; QUANTUM DOTS;

D O I：

10.1016/j.addr.2014.06.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nano-scaled devices are a promising platform for specific detection of pathological targets, facilitating the analysis of biological tissues in real-time, while improving the diagnostic approaches and the efficacy of therapies. Herein, we review nanodevice approaches, including liposomes, nanoparticles and polymeric nanoassemblies, such as polymeric micelles and vesicles, which can precisely control their structure and functions for specifically interacting with cells and tissues. These systems have been successfully used for the selective delivery of reporter and therapeutic agents to specific tissues with controlled cellular and subcellular targeting of biomolecules and programmed operation inside the body, suggesting a high potential for developing the analysis for nano-pathophysiology. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：35 / 52

页数：18

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