(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist

被引：24

作者：

Gasparini, F ^{[1
]}

Inderbitzin, W

Francotte, E

Lecis, G

Richert, P

Dragic, Z

Kuhn, R

Flor, PJ

机构：

[1] Novartis Pharam AG, Nervous Syst Res, CH-4002 Basel, Switzerland

[2] Novartis Pharma AG, Core Technol, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(00)00197-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1241 / 1244

页数：4

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