Polymorphisms in the PTX1 may not be associated with ischemic stroke susceptibility

Objective: Ischemic stroke is a global health burden due to the increasingly higher incidence rate and mortality rate. Etiological research into the role of genetics in this heterogeneous disease may have diagnostic and prognostic implications. The present study was designed to assess the association between PTX1 SNPs: -717A>G and -286C>T>A, and ischemic stroke risk. Methods: Risk of ischemic stroke was estimated using summary ORs. The fixed effects model was performed in calculating the pooled ORs. All statistical data were analyzed with STATA software. Results: We combined 4,604 subjects for SNP -717A>G and 3,093 subjects for SNP -286C>T>A. SNP -717A>G was not found to be significantly associated with ischemic stroke risk (GG vs. AA, OR = 1.12, 95% CI = 0.83-1.50, P-Het = 0.207; GG + GA vs. AA, OR = 1.04, 95% CI = 0.93-1.17, P-Het = 0.533; GG vs. GA + AA, OR = 1.10, 95% CI = 0.82-1.47, P-Het = 0.220). Meta-analysis of SNP -286C>T>A also demonstrated no statistical evidence of a significant association with ischemic stroke (AA vs. CC, OR = 0.86, 95% CI = 0.59-1.25, P-Het = 0.348; AA vs. CC, OR = 0.92, 95% CI = 0.80-1.06, P-Het = 0.609; AA vs. CC, OR = 0.89, 95% CI = 0.62-1.30, P-Het = 0.374). Conclusions: These results suggest that the PTX1 gene polymorphisms may not be associated with a predisposition to ischemic stroke.