Lessons from knockout and transgenic mice for infertility in men

被引：41

作者：

Venables, JP ^{[1
]}

Cooke, HJ ^{[1
]}

机构：

[1] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2000年 / 23卷 / 09期

基金：

英国医学研究理事会;

关键词：

spermatogenesis; meiosis; spermiogenesis; infertility; knockout; transgenic; promoter; UTR;

D O I：

10.1007/BF03343780

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review concentrates on the clear cases where knocking out a gene in mice has caused male infertility and thus comes near to proving that the gene plays a role in the development of sperm. Knockout mice have been created with primary defects at every stage of spermatogenesis thus creating a framework for decoding the genetic hierarchy that causes male germ cell differentiation. As well as defining essential genes in vivo experiments have defined promoter and untranslated sequences responsible for the expression of proteins at all the spermatogenic stages. In conclusion knockout mice remain the ultimate test of spermatogenic hypotheses as well as providing detailed information about this complex process. (J. Endocrinol. Invest. 23: 584-591, 2000) (C) 2000, Editrice Kurtis.

引用

页码：584 / 591

页数：8

共 100 条

[1]

Albanesi C, 1996, DEVELOPMENT, V122, P1291

[2] Targeted mutagenesis of the endogenous mouse Mis gene promoter:: In vivo definition of genetic pathways of vertebrate sexual development [J].

Arango, NA ;

Lovell-Badge, R ;

Behringer, RR .

CELL, 1999, 99 (04) :409-419

[3] Specific aspects of the ubiquitin system in spermatogenesis [J].

Baarends, WM ;

van der Laan, R ;

Grootegoed, JA .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2000, 23 (09) :597-604

[4]

BABA T, 1994, J BIOL CHEM, V269, P31845

[5] Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over [J].

Baker, SM ;

Plug, AW ;

Prolla, TA ;

Bronner, CE ;

Harris, AC ;

Yao, X ;

Christie, DM ;

Monell, C ;

Arnheim, N ;

Bradley, A ;

Ashley, T ;

Liskay, RM .

NATURE GENETICS, 1996, 13 (03) :336-342

[6] MALE-MICE DEFECTIVE IN THE DNA MISMATCH REPAIR GENE PMS2 EXHIBIT ABNORMAL CHROMOSOME SYNAPSIS IN MEIOSIS [J].

BAKER, SM ;

BRONNER, CE ;

ZHANG, L ;

PLUG, AW ;

ROBATZEK, M ;

WARREN, G ;

ELLIOTT, EA ;

YU, JA ;

ASHLEY, T ;

ARNHEIM, N ;

FLAVELL, RA ;

LISKAY, RM .

CELL, 1995, 82 (02) :309-319

[7]

Barlow C, 1998, DEVELOPMENT, V125, P4007

[8]

Bartell JG, 1996, J BIOL CHEM, V271, P4046, DOI 10.1074/jbc.271.8.4046

[9] RNA-binding protein TIAR is essential for primordial germ cell development [J].

Beck, ARP ;

Miller, IJ ;

Anderson, P ;

Streuli, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2331-2336

[10] Regulatory role of p27kip1 in the mouse and human testis [J].

Beumer, TL ;

Kiyokawa, H ;

Roepers-Gajadien, HL ;

van den Bos, LAC ;

Lock, TMTW ;

Gademan, IS ;

Rutgers, DH ;

Koff, A ;

de Rooij, DG .

ENDOCRINOLOGY, 1999, 140 (04) :1834-1840

← 1 2 3 4 5 6 7 8 9 10 →