Primary central nervous system lymphoma in daily practice and the role of autologous stem cell transplantation in relapsed disease: A retrospective multicenter study

被引：2

作者：

Erkurt, Mehmet Ali ^{[1
]}

Berber, Ilhami ^{[1
]}

Tekgunduz, Emre ^{[2
]}

Dogu, Mehmet Hilmi ^{[3
]}

Korkmaz, Serdal ^{[4
]}

Demir, Cengiz ^{[5
]}

Yilmaz, Mehmet ^{[6
]}

Akay, Olga Meltem ^{[7
]}

Pala, Cigdem ^{[8
]}

Bilen, Yusuf ^{[9
]}

Kaya, Emin ^{[1
]}

Sari, Ismail ^{[3
]}

Sencan, Mehmet ^{[10
]}

Kuku, Irfan ^{[1
]}

Altuntas, Fevzi ^{[2
,11
]}

Dal, Mehmet Sinan ^{[2
]}

Aydogdu, Ismet ^{[12
]}

机构：

[1] Inonu Univ, Fac Med, Dept Hematol, TR-44069 Malatya, Turkey

[2] Ankara Oncol Hosp, Hematol & HCT Clin, Ankara, Turkey

[3] Pamukkale Univ, Fac Med, Dept Hematol, Denizli, Turkey

[4] Kayseri Trainer & Res Hosp, Div Hematol, Kayseri, Turkey

[5] Yuzuncu Yil Univ, Fac Med, Dept Hematol, Van, Turkey

[6] Antep Univ, Fac Med, Dept Hematol, Gaziantep, Turkey

[7] Osmangazi Univ, Fac Med, Dept Hematol, Eskisehir, Turkey

[8] Erciyes Univ, Fac Med, Dept Hematol, Kayseri, Turkey

[9] Ataturk Univ, Fac Med, Dept Hematol, Erzurum, Turkey

[10] Cumhuriyet Univ, Fac Med, Dept Hematol, Sivas, Turkey

[11] Yildirim Beyazit Univ, Fac Med, Dept Internal Med, Div Hematol, Ankara, Turkey

[12] Celal Bayar Univ, Fac Med, Dept Hematol, Manisa, Turkey

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2016年 / 54卷 / 01期

关键词：

Autologous stem cell transplantation; CNS lymphoma; PCNSL; Methotrexate; High-dose chemotherapy; PRIMARY CNS LYMPHOMA; HIGH-DOSE METHOTREXATE; WHOLE-BRAIN RADIOTHERAPY; RECURRENT PRIMARY CNS; INTENSIVE CHEMOTHERAPY; PHASE-II; IMMUNOCOMPETENT PATIENTS; DEFERRED RADIOTHERAPY; INTRAOCULAR LYMPHOMA; DIAGNOSIS;

D O I：

10.1016/j.transci.2016.01.018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the course of 54 patients presenting with primary central nervous system lymphoma, who were treated in daily practice. The patients were treated with chemotherapy and/or radiotherapy and/or intrathecal chemotherapy. At a median follow-up period of 23 months (range 1-71), median relapse-free survival (RFS) and overall survival (OS) were not reached. Estimated 2-year RFS and OS rates were 42% and 48%, respectively. Ten relapsed PCNSL patients underwent ASCT. Complete remission rate of these patients was 40%, with 20% treatment-related mortality. Estimated 2-year RFS and OS rates were 37% and 40%, respectively. The prognosis of patients with PCNSL, who received off-study treatment, is still dismal. (c) 2016 Elsevier Ltd. All rights reserved.

引用

页码：80 / 84

页数：5

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